A. Saviola

Publications42
h-index14
Citations578
Highly Influential Citations26
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Comparative venomics of the Prairie Rattlesnake (Crotalus viridis viridis) from Colorado: Identification of a novel pattern of ontogenetic changes in venom composition and assessment of the…
Molecular basis for prey relocation in viperid snakes
TLDR
These findings reveal the evolutionary significance of free disintegrins in venoms as the molecular mechanism in vipers allowing for effective relocation of envenomated prey.
Evaluation of cytotoxic activities of snake venoms toward breast (MCF-7) and skin cancer (A-375) cell lines
TLDR
It is confirmed that many venoms contain cytotoxic compounds, including catalytic PLA2s, and several venoms also showed significant differential toxicity toward the two cancer cell lines, indicating that several previously uncharacterized venoms could contain promising lead compounds for drug development.
Chemosensory responses to chemical and visual stimuli in five species of colubrid snakes
Snakes utilize chemical and visual stimuli during predation, however the emphasis on these cues and which cues are used to initiate predation varies among species. For example, rattlesnakes using the…
Rear-fanged snake venoms: an untapped source of novel compounds and potential drug leads
TLDR
Recent progress in the analysis of snake venom toxins, particularly disintegrins and proteases from viper venoms, is discussed, focusing on several studies of specific venom components as well as transcriptomic and proteomic surveys.
The disintegrin tzabcanin inhibits adhesion and migration in melanoma and lung cancer cells.
Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam.
Understanding Biological Roles of Venoms Among the Caenophidia: The Importance of Rear-Fanged Snakes.
TLDR
Relatively few rear-fanged snake venoms have been characterized, and basic natural history data are largely lacking, but directed sampling of specialized species indicates that novel compounds are likely among these specialists, particularly among those species feeding on invertebrates such as scorpions and centipedes.
Venom phenotypes of the Rock Rattlesnake (Crotalus lepidus) and the Ridge‐nosed Rattlesnake (Crotalus willardi) from México and the United States
Venom Ontogeny in the Mexican Lance-Headed Rattlesnake (Crotalus polystictus)
TLDR
Venom samples collected from adult and neonate Crotalus polystictus from Estado de México were subjected to enzymatic and electrophoretic analyses, toxicity assays, and MALDI-TOF mass spectrometry, and a pooled sample of adult venom was analyzed by shotgun proteomics.
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