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Molecular basis for prey relocation in viperid snakes
These findings reveal the evolutionary significance of free disintegrins in venoms as the molecular mechanism in vipers allowing for effective relocation of envenomated prey.
Evaluation of cytotoxic activities of snake venoms toward breast (MCF-7) and skin cancer (A-375) cell lines
It is confirmed that many venoms contain cytotoxic compounds, including catalytic PLA2s, and several venoms also showed significant differential toxicity toward the two cancer cell lines, indicating that several previously uncharacterized venoms could contain promising lead compounds for drug development.
Chemosensory responses to chemical and visual stimuli in five species of colubrid snakes
Snakes utilize chemical and visual stimuli during predation, however the emphasis on these cues and which cues are used to initiate predation varies among species. For example, rattlesnakes using the
Rear-fanged snake venoms: an untapped source of novel compounds and potential drug leads
Recent progress in the analysis of snake venom toxins, particularly disintegrins and proteases from viper venoms, is discussed, focusing on several studies of specific venom components as well as transcriptomic and proteomic surveys.
Understanding Biological Roles of Venoms Among the Caenophidia: The Importance of Rear-Fanged Snakes.
Relatively few rear-fanged snake venoms have been characterized, and basic natural history data are largely lacking, but directed sampling of specialized species indicates that novel compounds are likely among these specialists, particularly among those species feeding on invertebrates such as scorpions and centipedes.
Venom Ontogeny in the Mexican Lance-Headed Rattlesnake (Crotalus polystictus)
Venom samples collected from adult and neonate Crotalus polystictus from Estado de México were subjected to enzymatic and electrophoretic analyses, toxicity assays, and MALDI-TOF mass spectrometry, and a pooled sample of adult venom was analyzed by shotgun proteomics.