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A Novel Transrepression Pathway of c-Myc
The protooncogene product c-Myc plays a role in transcription regulation both for activation and repression. While transactivation pathways of c-Myc either from the N-proximal or the C-proximalExpand
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MM-1 facilitates degradation of c-Myc by recruiting proteasome and a novel ubiquitin E3 ligase.
We have reported that a novel c-Myc-binding protein, MM-1, repressed the E-box-dependent transcription activity of c-Myc by recruiting the HDAC1 complex via TIF1beta/KAP1, a transcriptionalExpand
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RECRUITMENT OF A TRANSCRIPTIONAL COREPRESSOR COMPLEX TO c-Myc BY MM-1, A c-Myc-BINDING PROTEIN*
The protooncogene product c-Myc plays a role in tran-scription regulation both for activation and repression.While transactivation pathways of c-Myc either from theN-proximal or the C-proximal regionExpand
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High glucose enhances the gene expression of interleukin-8 in human endothelial cells, but not in smooth muscle cells: possible role of interleukin-8 in diabetic macroangiopathy
Summary We examined the effect of high glucose concentrations on the production of interleukin(IL)-8, which seems to be important for the development of atherosclerosis, in cultured human aorticExpand
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The IL-8 production in endothelial cells is stimulated by high glucose.
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Repression of the c‐fms gene in fibroblast cells by c‐Myc‐MM‐1‐TIF1β complex
MM‐1 has been reported to repress the E‐box‐dependent transcription activity of c‐Myc by recruiting histone deacetylase 1 complex via TIF1β/KAP1. In this study, to identify target genes forExpand
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