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Activation and desensitization by cyclic antidepressant drugs of α2-autoreceptors, α2-heteroreceptors and 5-HT1A-autoreceptors regulating monoamine synthesis in the rat brain in vivo
These findings indicate that acute treatment with cyclic antidepressant drugs results in activation of inhibitory α2C-autoreceptors, α2A-heteroreceptorors and/or 5-HT1A-autorceptors regulating the synthesis of dopa/NA or 5- HTP/5-HT after chronic desipramine and fluoxetine. Expand
The imidazoline receptor ligand 2-(2-benzofuranyl)-2-imidazoline is a dopamine-releasing agent in the rat striatum in vivo
The I2-imidazoline receptor ligand 2-BFI is also a DA releasing agent in brain, and consequently a DA indirect agonist in vivo. Expand
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT1A receptors modulating serotonin and dopamine synthesis in rat brain in vivo
The results indicate that chronic ethanol and more clearly the spontaneous withdrawal from chronic ethanol induce supersensitivity of 5-HT(1A)-auto/heteroreceptors modulating the synthesis of5-HT and DA in rat brain. Expand
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.
The results indicate that beta-carbolines bind with high affinity to imidazoline I2B receptors, and similarly to I2 ligands (LSL 60101) can block the behavioural and biochemical effects of opiate withdrawal. Expand
Supersensitivity of 5-HT1A-autoreceptors and α2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats
It is concluded that morphine addiction is associated with supersensitivity of 5-HT1A serotonin receptors and α2-adrenoceptors (autoreceptor and heteroreceptors) that modulate the synthesis of monoamines in brain. Expand
Effects of imidazoline receptor ligands on monoamine synthesis in the rat brain in vivo
Most imidazoline drugs modulated the synthesis of brain monoamines through interaction with α2-adrenoceptors or 5-HT1A receptors through contact with α1/α2 receptors, and the results do not provide functional evidence for the existence of presynaptic imidrazoline receptors regulating the synthesisof monoamines in the rat brain. Expand
Effects of Imidazoline Drugs on Tyrosine and Tryptophan Hydroxylase Activity in Rat Brain in Vivo