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Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10.
The results indicate that in human monocytes, the mechanism(s) of IL-10 suppression of both IL-12 p40 and IL- 12 p35 genes is primarily seen at the transcriptional level, and that the induction of the IL-11 p35 and p 35 genes have different requirements for de novo protein synthesis. Expand
Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells.
It is demonstrated that metacyclic L. major promastigotes are poor inducers of IL-12 in vitro in fresh human PBMC and monocytes and the development of an evasion mechanism as the Leishmania promastIGotes mature to infectious forms is suggested. Expand
Leishmanial antigens in the diagnosis of active lesions and ancient scars of American tegumentary leishmaniasis patients.
The cellular, vascular and neural patterns could be applied in the immunodiagnosis of active and cicatricial lesions in which leishmaniasis is suspected. Expand
Impact of malnutrition on immunity and infection
The magnitude of this problem, as well as its direct effect on the immune system and how it results in higher susceptibility to infections are described. Expand
Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon‐γ recovery and reduction of lung injury
The results show that the most significant effect of pHSP65 was the stimulation of CD8+ lung cell activation, interferon‐γ recovery and reduction of lung injury. Expand
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae.
In this study, in vivo beta-glucan administration primed spleen cells for a higher production of IL-12 and TNF-alpha when S. aureus was used as a stimulus and some immunomodulatory activities not yet described for beta- glucan were observed in this work. Expand
Septic arthritis: immunopathogenesis, experimental models and therapy
Some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction and the improvement of therapy by association of antibiotics with down-modulation of immunity are discussed. Expand
Immune modulation induced by tuberculosis DNA vaccine protects non‐obese diabetic mice from diabetes progression
The results show that DNA‐HSP65 can protect NOD mice against diabetes and can therefore be considered in the development of new immunotherapeutic strategies. Expand
Production of interleukin-12.
Interleukin-12: an immunoregulatory cytokine produced by B cells and antigen-presenting cells.
Both in vivo and in vitro, IL-12 is a powerful inducer of T helper type 1 (Th1) response, whereas it inhibits Th2-type responses. Expand