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Differential effects of social stress on central serotonergic activity and emotional reactivity in Lewis and spontaneously hypertensive rats
The psychoneuroendocrine responses to social stress may have a genetic origin, and that the use of socially stressed Lewis and spontaneously hypertensive rats may provide an important paradigm to study adaptive processes is shown. Expand
Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat.
It was found that H animals secreted less ACTH and corticosterone during and following the termination of stress than did nonhandled (NH) controls, and H animals were more sensitive than NH animals to the inhibitory effects of either B or dexamethasone on stress-induced adrenocortical activity. Expand
The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life
It is shown how early handling influences the neurochemical development of certain brain regions that regulate the adrenocortical response to stress, preventing excessive exposure to the highly catabolic adrenal steroids in later life. Expand
Male Fischer 344 and Lewis rats display differences in locomotor reactivity, but not in anxiety-related behaviours: relationship with the hippocampal serotonergic system
This study suggests that both strains display high levels of anxiety but markedly differ in their locomotor activities, whether the latter strain difference is due to alterations in the HPA axis and/or the central serotonergic systems. Expand
Behavioral and neuroendocrine reactivity to stress in the WKHA/WKY inbred rat strains: a multifactorial and genetic analysis
WKHA rats, compared to WKYs, were more active in a familiar as well as in novel environments and exhibited also less anxiety-related behaviors and lower neuroendocrine responses. Expand
Preliminary evidence is lent for involvement of sex and genetics as sources of individual differences in bioadaptation to stress in mice subjected to either acute or 5 days of repeated restraint in ventilated, 50 ml centrifuge tubes. Expand
Contribution of corticosterone to cued versus contextual fear in rats
Several studies have suggested a positive relationship between circulating corticosterone levels and contextual conditioning. However, a positive relationship between circulating corticosteroneExpand
Distribution of cells expressing vasoactive intestinal peptide/peptide histidine isoleucine-amide precursor messenger rna in the rat brain
The predominance of vasoactive intestinal peptide/peptide histidine isoleucine-amide messenger RNA-containing neurons in the cerebral cortex, suprachiasmatic nucleus and thalamus suggest that vaso Active intestine peptide is mainly involved in the control of cortical informations, circadian rhythms and sensory perception in agreement with several physiological data. Expand
Behavior and pituitary-adrenal function in large white and Meishan pigs.
The data suggest that the hypercortisolism of MS pigs is of adrenal origin, and related to extrapituitary factors that control the adrenal sensitivity during the light phase of the diurnal cycle. Expand
Autoradiographic localization of glucocorticosteroid and progesterone binding sites in the human post-mortem brain.
The hippocampus seems to possess mainly glucocorticosteroid binding sites whereas the entorhinal cortex and the subiculum reveal the presence of both glucoc Corticosteroids and progesterone binding sites, and the amygdaloid complex and the fimbria show a high density of glucocORTicosteroidal binding sites. Expand