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gamma-Tubulin is present in acentriolar MTOCs during early mouse development.
Early mouse embryos allowed us to study the location of gamma-tubulin in animal cells in the absence of centrioles and found that it specifically-stained the spindle poles and the cytoplasmic microtubule organizing centers in metaphase II oocytes and in mitosis during the cleavage stages, while no interphase staining could be detected during cleavage.
Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis.
It is suggested that their cleavage allows both the detachment of NE from chromatin and the clustering of NPCs in the plane of the membrane, two conserved morphological features of apoptosis observed in this study.
Phosphorylation of ezrin on threonine T567 plays a crucial role during compaction in the mouse early embryo.
Ezrin Becomes Restricted to Outer Cells Following Asymmetrical Division in the Preimplantation Mouse Embryo
Ezrin is the first cytocortical protein described that is totally segregated in outer cells at the 16-cell stage after an asymmetrical division in the mouse embryo, and remains associated with the microvillous pole during the transition from the 8- to 16- cell stage.
A major posttranslational modification of ezrin takes place during epithelial differentiation in the early mouse embryo.
- S. Louvet-Vallée, N. Dard, A. Santa-Maria, J. Aghion, B. Maro
- BiologyDevelopmental biology
- 1 March 2001
It is shown that the formation of microvilli at the apical surface of the outer cells of ICM correlates with a major posttranslational modification of ezrin, and that this posttranslated modification is not controlled by a serine/threonine kinase but an O-glycosylation may partially contribute to it.
In vivo functional analysis of ezrin during mouse blastocyst formation.
The results suggest that, in addition to its role in microvilli organization, ezrin is involved in the formation of a functional epithelium through a still unknown mechanism.
Gp330 is specifically expressed in outer cells during epithelial differentiation in the preimplantation mouse embryo.
The results show that gp330 is first synthesized in 16-cell stage embryos and that its appearance is restricted to outer cells until the blastocyst stage, and its expression is repressed in inner cells at a post-transcriptional level.
Sister chromatid exchange induced by several types of coffees in Chinese hamster ovary cells.
- A. Santa-Maria, A. López, M. M. Díaz, A. I. Ortiz, C. Caballo
- Biology, MedicineTeratogenesis, carcinogenesis, and mutagenesis
The results indicate that caffeinated instant coffees showed higher genotoxic activity than decaffeinated coffees.
Analysis of cytogenetic damage induced in CHO cells by the pyrethroid insecticide fenvalerate.
- C. Caballo, A. Herrera, C. Barrueco, A. Santa-Maria, F. Sanz, E. de la Peña
- BiologyTeratogenesis, carcinogenesis, and mutagenesis
Results indicate that fenvalerate in the presence of S9-mix is able significantly to increase the frequency of CA, while in the SCE test this increase occurred both in the Presence and in the absence of a rat liver activation system.
Apoptosis induced by different doses of caffeine on Chinese hamster ovary cells
Caffeine has been investigated for its potential mutagenic activity to bacteria, fungi and mammalian cells in culture, and at high concentrations it is also an inducer of apoptosis. Caffeine can…