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LM 427, a new spiropiperidylrifamycin: in vitro and in vivo studies.
TLDR
The spiropiperidylrifamycin LM 427 displays a broad spectrum of potent antibacterial activity in vitro and in vivo and is particularly effective in the therapy of experimental tubercular infections of mice.
Biological activity of a new class of rifamycins. Spiro-piperidyl-rifamycins.
TLDR
In vivo (experimental infections of mice) the optimal therapeutic activity against M. tuberculosis is shown by compounds bearing 3 approximately 5 carbon atoms as a linear or branched side chain; in comparison with rifampicin, the potency of these derivatives is 2 approximately 3 times higher.
Activity of distamycin A on the induction of adaptive enzymes in Escherichia coli.
TLDR
The enzyme synthesized in the presence of subinhibitory concentrations of distamycin A showed the same kinetic behaviour as β-galacto-sidase induced under normal conditions, so it does not seem that distamyin A causes a decrease of the concentration of inducer.
Laboratory evaluation of a new long-acting 3-azinomethylrifamycin FCE 22250.
TLDR
In the experimental mice infection sustained by Mycobacterium tuberculosis H37Rv, FCE 22250 shows an efficacy 14 times higher than rifampicin and is still therapeutic when administered once every three weeks.
Preservation of viable flexibacteria at low temperatures.
Most of the 28 species (91 strains) of flexibacteria tested without additives survived after freezing in liquid nitrogen (−196 °C): they included all six Microscilla spp., all three Cytophaga spp.,
ACTIVITY OF DISTAMYCIN A ON THE TRANSFER OF DRUG RESISTANCE IN GRAM‐NEGATIVE CLINICAL ISOLATES
  • A. Sanfilippo
  • Biology
    Annals of the New York Academy of Sciences
  • 1 June 1971
TLDR
Findings suggest the hypothesis of a possible interference of distamycin A with the resistance transfer processes in some strains of gramnegative clinical isolates.
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