A. Sandoval

Publications47
h-index16
Citations830
Highly Influential Citations18
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Ghrelin inhibits proliferation and increases T-type Ca2+ channel expression in PC-3 human prostate carcinoma cells.
ZD7288 inhibits low-threshold Ca(2+) channel activity and regulates sperm function.
Rim1 modulates direct G-protein regulation of Cav2.2 channels
TLDR
The data suggest that Rim1-induced facilitation of neurotransmitter release may come as a consequence of a decrease in the inhibitory pathway carried by G-proteins that contributes, together with the slowing of channel inactivation, to maintain Ca2+ influx under prolonged activity.
Intramembrane Charge Movement Associated with Endogenous K+ Channel Activity in HEK-293 Cells
TLDR
Gating currents were unambiguously resolved after ionic current blockade enabling this first report of intramembrane charge movement in HEK-293 cells arising entirely from endogenous K+ channel activity, and providing valuable information concerning the activation mechanism of voltage-gated K+ channels in these cells.
The S218L familial hemiplegic migraine mutation promotes deinhibition of Cav2.1 calcium channels during direct G-protein regulation
TLDR
Functional consequences of FHM-1 mutations appear as the consequence of the alteration of both intrinsic biophysical properties and of the main inhibitory G-protein pathway of Cav2.1 channels, which seems in line with the less severe associated clinical phenotype in patients.
The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin.
Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells
TLDR
It is shown that Ado increases proliferation and migration in a triple negative breast cancer model, the MDA-MB 231 cell line, which suggests important roles of the A2B receptors and NaV1.5 channels in the Ado-induced increase in proliferation and migrated cells.
Cdk5-Dependent Phosphorylation of CaV3.2 T-Type Channels: Possible Role in Nerve Ligation-Induced Neuropathic Allodynia and the Compound Action Potential in Primary Afferent C Fibers
TLDR
The present work shows that the exacerbated expression of Cdk5 in a preclinical model of neuropathic pain increases the functional expression of CaV3.2 channels, and suggests that increased channel activity by Cdk 5-mediated phosphorylation after SNL contributes nerve injury-induced tactile allodynia.
Glycosylation of asparagines 136 and 184 is necessary for the α2δ subunit‐mediated regulation of voltage‐gated Ca2+ channels
Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit.
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