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Tuberculosis Drug Resistance Mutation Database
Andreas Sandgren and colleagues describe a new comprehensive resource on drug resistance mutations inM. tuberculosis.
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Effect of clonal and serotype-specific properties on the invasive capacity of Streptococcus pneumoniae.
The present study compares the molecular epidemiology of Streptococcus pneumoniae causing invasive disease and carriage, respectively, in one geographic area (Stockholm, Sweden) during a specificExpand
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Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries
Latent tuberculosis infection (LTBI) is characterised by the presence of immune responses to previously acquired Mycobacterium tuberculosis infection without clinical evidence of active tuberculosisExpand
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Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen.
BACKGROUND Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. The role of the different capsular and clonal types in invasive disease severity remains to be defined. Expand
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Toll‐like receptor 9 acts at an early stage in host defence against pneumococcal infection
Toll‐like receptor 9 (TLR9) induces an inflammatory response by recognition of unmethylated CpG dinucleotides, mainly present in prokaryotic DNA. So far, TLR9‐deficient mice have been shown to beExpand
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Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden.
BACKGROUND The incidence and severity of invasive group A streptococcal infection demonstrate great variability over time, which at least, in part, seems to be related to group A streptococcal typeExpand
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Interferon-&ggr; release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis
We conducted a systematic review and meta-analysis to compare the accuracy of the QuantiFERON-TB® Gold In-Tube (QFT-G-IT) and the T-SPOT®.TB assays with the tuberculin skin test (TST) for theExpand
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Myeloid differentiation factor 88‐dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice
The Toll‐like receptors (TLRs) and the myeloid differentiation factor 88 (MyD88) are key players in the activation of the innate immune defence during microbial infections. Using different murineExpand
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Interferon-&ggr; release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis
Interferon-&ggr; release assays (IGRAs) are now established for the immunodiagnosis of latent infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for the diagnosisExpand
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Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World HealthExpand
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