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Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies.
This paper presents a meta-analysis of high-resolution human leukocyte antigen (HLA) allele frequency data describing 497 population samples. Most of the datasets were compiled from studies publishedExpand
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Impact of Selection and Demography on the Diffusion of Lactase Persistence
Background The lactase enzyme allows lactose digestion in fresh milk. Its activity strongly decreases after the weaning phase in most humans, but persists at a high frequency in Europe and someExpand
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Common and well-documented HLA alleles: 2012 update to the CWD catalogue.
We have updated the catalogue of common and well-documented (CWD) human leukocyte antigen (HLA) alleles to reflect current understanding of the prevalence of specific allele sequences. The originalExpand
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The Heterogeneous HLA Genetic Makeup of the Swiss Population
This study aims at investigating the HLA molecular variation across Switzerland in order to determine possible regional differences, which would be highly relevant to several purposes: optimizingExpand
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Immunogenetics as a tool in anthropological studies
The genes coding for the main molecules involved in the human immune system – immunoglobulins, human leucocyte antigen (HLA) molecules and killer‐cell immunoglobulin‐like receptors (KIR) – exhibit aExpand
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Human genetic differentiation across the Strait of Gibraltar
BackgroundThe Strait of Gibraltar is a crucial area in the settlement history of modern humans because it represents a possible connection between Africa and Europe. So far, genetic data wereExpand
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Genetic Evidence for Complexity in Ethnic Differentiation and History in East Africa
The Afro‐Asiatic and Nilo‐Saharan language families come into contact in Western Ethiopia. Ethnic diversity is particularly high in the South, where the Nilo‐Saharan Nyangatom and the Afro‐AsiaticExpand
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Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques
The Mamu-A, Mamu-B, and Mamu-DRB genes of the rhesus macaque show several levels of complexity such as allelic heterogeneity (polymorphism), copy number variation, differential segregation ofExpand
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HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity.
HLA-DRB1, -DQB1 and -DPB1 polymorphisms were investigated in two African populations, the Basse Lobaye Aka Pygmies of the Central African Republic, and a Bantu-speaking group from the DemocraticExpand
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The molecular determination of HLA-Cw alleles in the Mandenka (West Africa) reveals a close genetic relationship between Africans and Europeans.
HLA-Cw alleles were determined by high-resolution polymerase chain reaction-sequence-specific oligonucleotide probe (PCR-SSOP) oligotyping in a sample of 165 Mandenka, a population from EasternExpand
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