• Publications
  • Influence
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as "Nasu-Hakola disease," is a globally distributed recessively inherited disease leading to deathExpand
  • 489
  • 33
Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature.
Alexander disease (AD) in its typical form is an infantile lethal leucodystrophy, characterized pathologically by Rosenthal fibre accumulation. Following the identification of glial fibrillary acidicExpand
  • 114
  • 13
Validation of Italian multiple sclerosis quality of life 54 questionnaire
OBJECTIVES Health related quality of life (HRQOL) inventories are multi-dimensional measures of patient-centred health status developed for clinical research. The MS quality of life 54 (MSQOL-54) isExpand
  • 152
  • 12
Physical rehabilitation has a positive effect on disability in multiple sclerosis patients
Background: Although physical rehabilitation is commonly administered to MS patients, its efficacy has not been established. Objective: We assessed the efficacy of an inpatient physicalExpand
  • 196
  • 10
Expression of Drug Resistance Proteins Pgp, MRP1, MRP3, MRP5 AND GST-π in Human Glioma
SummaryChemotherapy in glioma is poorly effective: the blood–brain barrier and intrinsic and/or acquired drug resistance of tumor cells could partly explain this lack of major effect. We investigatedExpand
  • 174
  • 9
Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma
Intracavitary levels of VEGF, bFGF, IL-8 and IL-12 were evaluated by ELISA in 45 patients, 7 with recurrent anaplastic astrocytoma (rAA), 12 with glioblastoma (GBM) and 26 with recurrent glioblastomaExpand
  • 131
  • 7
Nestin, PDGFR-β, CXCL12 and VEGF in gliomapatients: Different profiles of (Pro-Angiogenic) molecule expression are related with tumor grade and may provide prognostic information
Angiogenesis is a key event in the natural progression of gliomas. Nestin, a marker for multipotential neuroepithelial stem cells, is detected in neuroepithelial tumors and in proliferatingExpand
  • 57
  • 6
Impaired Differentiation of Osteoclasts in TREM-2–deficient Individuals
TREM-2 is an immunoglobulin-like cell surface receptor associated with DAP12/KARAP that activates monocyte-derived dendritic cells (DCs) in vitro. Recently, it has been shown that genetic defects ofExpand
  • 200
  • 5
Lycopersicon esculentum lectin: an effective and versatile endothelial marker of normal and tumoral blood vessels in the central nervous system.
The binding of Lycopersicon esculentum lectin (LEA) to the vascular endothelium was studied in the central nervous system of rat, mouse and guinea pig at different developmental ages, and in aExpand
  • 58
  • 5
Glioblastoma‐derived tumorospheres identify a population of tumor stem‐like cells with angiogenic potential and enhanced multidrug resistance phenotype
We investigated in vitro the properties of selected populations of cancer stem‐like cells defined as tumorospheres that were obtained from human glioblastoma. We also assessed their potential andExpand
  • 245
  • 4