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Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy.
During the past few years, a group of cyclopenta[b]benzofurans from the plant genus Aglaia has received broad scientific attention as interesting natural product lead compounds with potentialExpand
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New indole alkaloids from the bark of Alstonia scholaris.
A new indole alkaloid, akuammiginone (1), and a new glycosidic indole alkaloid, echitamidine-N-oxide 19-O-beta-d-glucopyranoside (2), together with the five known alkaloids, echitaminic acid (3),Expand
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Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras.
During a search for inhibitors of oncogenic K-Ras, we detected two known and two new examples of the rare neoantimycin structure class from a liquid cultivation of Streptomyces orinoci, andExpand
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Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins*
Background: Ras proteins must be plasma membrane-localized for biological activity. Results: A high content screen identified staurosporines as inhibitors of Ras plasma membrane localization andExpand
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Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)
Activity‐guided fractionation of an EtOAc‐soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical‐scavenging assay, led to the isolationExpand
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Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Pharmacological targeting of transcription factors holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individualExpand
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Small-Molecule Inhibitors of the SOX18 Transcription Factor.
Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades. This is mostly due to standard drug discovery approaches centered on blockingExpand
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Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
Activity-guided fractionation of hexanes- and CHCl 3-soluble extracts of Amomum aculeatum leaves, collected in Indonesia, led to the isolation of three new dioxadispiroketal-type ( 3- 5) and two newExpand
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Heterofibrins: inhibitors of lipid droplet formation from a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp.
A bioassay-guided search for inhibitors of lipid droplet formation in a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp., yielded six new compounds, fatty acids heterofibrinsExpand
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Constituents of the Leaves and Stem Bark of Aglaia foveolata.
The previously known potent cytotoxic agent silvestrol (1) (0.002% w/w yield) and five new flavagline derivatives (2-6) were isolated from the leaves of Aglaia foveolata collected in Indonesia. TheExpand
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