A. Salem

Publications254
h-index41
Citations5,958
Highly Influential Citations133
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Biodegradable Particles as Vaccine Delivery Systems: Size Matters
TLDR
It is suggested that the smaller the PLGA particle used to deliver antigen and adjuvants the stronger the antigen-specific cytotoxic T cell response generated.
Nanoparticle Delivery Systems in Cancer Vaccines
TLDR
Recent advances in colloidal and particulate nanoscale systems designed for cancer immunotherapy and the potential for these systems to translate into clinical cancer vaccines are reviewed.
3D Printing of Scaffolds for Tissue Regeneration Applications
TLDR
The criteria for printing viable and functional scaffolds, scaffolding materials, and 3DP technologies used to print scaffolds for tissue engineering are discussed and could potentially help to meet the demand by patients for tissues and organs without having to wait or rely on donors for transplantation.
Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo
TLDR
The leukocyte–inspired particles have adhesion efficiencies similar to that of leukocytes and were shown to target each of the major inducible endothelial cell adhesion molecules that are up-regulated at sites of pathological inflammation.
Multifunctional nanorods for gene delivery
TLDR
A non-viral gene-delivery system based on multisegment bimetallic nanorods that can simultaneously bind compacted DNA plasmids and targeting ligands in a spatially defined manner is presented, which allows precise control of composition, size and multifunctionality of the gene-Delivery system.
Optimization of Yield in Magnetic Cell Separations Using Nickel Nanowires of Different Lengths
TLDR
Ferromagnetic nanowires are shown to perform both high yield and high purity single‐step cell separations on cultures of NIH‐3T3 mouse fibroblast cells, and are robust when the diameter of the cell is changed within the same cell line using mitomycin‐C.
Interactions of 3T3 fibroblasts and endothelial cells with defined pore features.
TLDR
Fibroblast cells displayed a co-operative pattern of cell spreading in which pores with diameters greater than the cell dimensions were bridged by groups of cells using their neighbors as supports and endothelial cells were unable to use neighbors as support structures and failed to bridge pores greater thanThe cell diameter.
Innovative strategies for co-delivering antigens and CpG oligonucleotides.
Silica Nanoparticle-Generated ROS as a Predictor of Cellular Toxicity: Mechanistic Insights and Safety by Design.
TLDR
Overall, spectroscopic and in vitro studies correlate well and implicate production of ROS from a surface-catalyzed reaction as a predictor of cellular toxicity, and demonstrate that mesoporous materials are intrinsically less toxic than nonporous materials, and that surface functionalization can mitigate toxicity in non porosity materials by reducing free radical production.
Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses
TLDR
The attention is focused on, but not limited to, the generation of antitumor immunity where the importance of particle size and co-delivery of antigen and adjuvant is stressed.
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