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5-HT2 receptor blockade by ICI 169,369 and other 5-HT2 antagonists modulates the effects of D-2 dopamine receptor blockade.
The blockade of D-2 receptors by haloperidol results in a compensatory increase in rat striatal DA metabolism, which is enhanced by ICI 169,369, and data suggest that the 5-HT2 component of these compounds, by enhancingDA metabolism, may act to attenuate the blockade of striatal D- 2 receptors by these compounds.
Seroquel: biochemical profile of a potential atypical antipsychotic
Seroquel and the atypical antipsychotic clozapine were compared using a number of biochemical measures in rats which are indicative of potential antipsychotic activity and possible extrapyramidal
Role of Glycine in the N‐Methyl‐d‐Aspartate‐Mediated Neuronal Cytotoxicity
It is demonstrated that NMDA‐mediated neurotoxicity is markedly potentiated by glycine and other amino acids, e.g., d‐serine, which indicates that glycine, operating through a strychnine‐insensitive glycine site, plays a central permissive role inNMDA‐ mediated neurotoxicity.
Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptor mechanisms.
It is postulated that stimulation of phosphoinositide hydrolysis is neither necessary nor sufficient for neurotoxicity, although only activation of NMDA receptors is involved in Ibo neurotoxicity.
Novel non-benzodiazepine anxiolytics
Concerning the molecular requirements for the inhibition of the uptake of racemic 3 H-norepinephrine into rat cerebral cortex slices by tricyclic antidepressants and related compounds.
The membrane amine pump mechanisms in rabbit aorta and rat cerebral cortex appear to have fundamentally similar properties but differ in at least one respect.