• Publications
  • Influence
5-HT2 receptor blockade by ICI 169,369 and other 5-HT2 antagonists modulates the effects of D-2 dopamine receptor blockade.
The effects of D-2 dopamine (DA) receptor blockade were modulated by ICI 169,369, a selective 5-hydroxytryptamine (5-HT)2 receptor antagonist, and by other 5-HT2 antagonists. Specifically, it appearsExpand
  • 89
  • 4
Seroquel: biochemical profile of a potential atypical antipsychotic
Seroquel and the atypical antipsychotic clozapine were compared using a number of biochemical measures in rats which are indicative of potential antipsychotic activity and possible extrapyramidalExpand
  • 130
  • 3
Inhibition of K(+)-evoked [3H]D-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: evidence for non-L/non-N voltage-sensitive calcium channels.
The effects of inhibitors of voltage-sensitive calcium channels (VSCC) on K(+)-evoked [3H]D-aspartate release from rat hippocampal slices and the K(+)-evoked increase in intracellular calcium inExpand
  • 55
  • 2
Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate.
Tracazolate (ICI 136,753) 4-butylamine-1-ethyl-6-methyl-1H-pyrazolo[3,4]pyridine-5-carboxylic acid ethyl ester is a non-benzodiazepine with anxiolytic-like activity in animal models. In contrast toExpand
  • 86
  • 1
Novel non-benzodiazepine anxiolytics
Several new non-benzodiazepine anxiolytics are reported. These include tracazolate, zopiclone, CL218,872, CGS9896, buspirone, MK-801 and fenobam. A comparison of anticonflict effects and propensityExpand
  • 105
  • 1
Role of Glycine in the N‐Methyl‐d‐Aspartate‐Mediated Neuronal Cytotoxicity
Abstract: Current evidence indicates that glutamate acting via the N‐methyl‐d‐aspartate (NMDA) receptor/ion channel complex plays a major role in the neuronal degeneration associated with a varietyExpand
  • 115
  • 1
Concerning the molecular requirements for the inhibition of the uptake of racemic 3 H-norepinephrine into rat cerebral cortex slices by tricyclic antidepressants and related compounds.
The relative potencies of tricycics and related compounds as inhibitors of the uptake of 3 H-norepinephrine into rat cerebral cortex have been determined. Kinetic studies indicate that theseExpand
  • 30
  • 1
Dopamine receptor occupancy in vivo: measurement using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ).
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) inactivates a variety of monoamine neurotransmitter receptors. In this report, protection against EEDQ-induced inactivation of D-1 and D-2 DAExpand
  • 55
  • 1
The effect of varying carbachol concentration on the slope of Schild plots of selective β‐adrenoceptor antagonists in the carbachol‐contracted guinea‐pig trachea
The effect of varying the level of smooth muscle tone induced by carbachol on the Schild analysis of atenolol (β1‐selective) and ICI 118,551 (β2‐selective) with salbutamol as agonist, on theExpand
  • 6
  • 1
6,7‐Dinitroquinoxaline‐2,3‐Dione Blocks the Cytotoxicity of N‐Methyl‐D‐Aspartate and Kainate, but Not Quisqualate, in Cortical Cultures
Abstract: Based on radioligand binding and electrophysiological studies, quinoxalinediones such as 6,7‐dinitroquinoxaline‐2,3‐dione (DNQX) have been shown to be potent competitive antagonists at theExpand
  • 17
  • 1