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Estrogen Prevents the Lipopolysaccharide-Induced Inflammatory Response in Microglia
TLDR
It is shown that estrogen exerts an anti-inflammatory activity on primary cultures of rat microglia, as suggested by the blockage of the phenotypic conversion associated with activation and by the prevention of lipopolysaccharide-induced production of inflammatory mediators. Expand
Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma.
TLDR
It is suggested that PGE2 is highly effective in preventing aspirin-induced asthma and this effect is mediated by inhibition of sulfidopeptide leukotriene production. Expand
Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans.
TLDR
The administration of oil samples with increasing amounts of orthodiphenolic compounds, namely hydroxytyrosol and oleuropein aglycone, results in a dose-dependent reduction in the urinary excretion of 8-iso-PGF(2alpha), and a statistically significant negative correlation between homovanillyl alcohol and HValc urinary concentrations suggests that this metabolite better reflects the in vivo activities of hydroxyTYrosol. Expand
Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients
TLDR
The role of ACh in the development of airway narrowing and airways inflammation in chronic obstructive pulmonary disease (COPD) is hypothesized to be related to each other. Expand
Lipid peroxidation and 5-lipoxygenase activity in chronic obstructive pulmonary disease.
TLDR
The results of this study suggest that enhanced oxidative stress in subjects with COPD is paralleled by the increased ability of neutrophils to synthesize the chemotactic factor LTB(4), and may ultimately contribute to the infiltration/activation of neutophils into the airways of subjectswith COPD. Expand
Olive Phenol Hydroxytyrosol Prevents Passive Smoking–Induced Oxidative Stress
TLDR
A low dose of hydroxytyrosol, administered through OMWW, reduces the consequences of sidestream smoke–induced oxidative stress in rats. Expand
Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.
TLDR
It is suggested that CSE promote the induction of COX-2 and contributes to the proinflammatory effects of PGE(2) in the airways of COPD subjects. Expand
Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15(S)-HETE into cellular phospholipids in cultured pulmonary epithelial cells.
TLDR
The ability of IL-4 to promote 15-LO activity and incorporation into cellular phospholipids of human lung epithelial cells may be important in airway inflammation and in modulation of the potential autocrine function of 15(S)-HETE. Expand
Structural identification of cytochrome P450-dependent arachidonate metabolites formed by rabbit medullary thick ascending limb cells.
TLDR
The medullary thick ascending limb of Henle's loop (mTALH) contributes importantly to the regulation of extracellular fluid volume and composition and metabolizes arachidonic acid (AA) chiefly by a cytochrome P450 monooxygenase pathway based on their reverse-phase high pressure liquid chromatography retention times. Expand
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