A. Sajantila

Publications267
h-index58
Citations14,626
Highly Influential Citations788
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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
TLDR
It is demonstrated that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.
View on Nature
Ancient human genomes suggest three ancestral populations for present-day Europeans
TLDR
It is shown that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians; and early European farmers, who were mainly of Near Eastern origin but also harboured west Europeanhunter-gatherer related ancestry.
View on Nature
A promoter-level mammalian expression atlas
TLDR
It is found that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles.
View on Nature
Evidence for variable selective pressures at MC1R.
TLDR
It is concluded that MC1R is under strong functional constraint in Africa, where any diversion from eumelanin production (black pigmentation) appears to be evolutionarily deleterious.
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Characteristics and frequency of germline mutations at microsatellite loci from the human Y chromosome, as revealed by direct observation in father/son pairs.
TLDR
The data indicate that the general mutational mechanism of microsatellites is independent of recombination, and mutation rates and characteristics of human Y-chromosomal microsatellite loci are consistent with those of autosomal microSatellites.
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Correlation between Genetic and Geographic Structure in Europe
View on Elsevier
Genes and languages in Europe: an analysis of mitochondrial lineages.
TLDR
It is argued that this apparent contradiction is attributable to the fact that genetic lineages and gene frequencies reflect different time perspectives on population history, the latter being more in concordance with linguistic evolution.
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CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
TLDR
The CYP2D6 diversity is far greater within than between populations and groups thereof, null or low-activity variants occur at high frequencies in various areas of the world, and linkage disequilibrium is lowest in Africa and highest in the Americas.
View on Wolters Kluwer
mtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration?
TLDR
It is concluded that human migrations between Egypt and Nubia probably occurred within the past few hundred to few thousand years and that the migration from north to south was either earlier or lesser in the extent of gene flow than the Migration from south to north.
View on PubMed
Genetic relationships of Asians and Northern Europeans, revealed by Y-chromosomal DNA analysis.
TLDR
The Y chromosome provides both information about population relationships in Asia and evidence for a substantial paternal genetic contribution of Asians to northern European populations such as the Finns.
View on PubMed
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