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Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat.
Topical application of siRNA to the skin should be an effective treatment for serious skin disorders, such as atopic dermatitis. However, it is difficult to introduce hydrophilic macromolecules,Expand
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Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin.
In atopic dermatitis, the concentration in the skin of sphingosylphosphorylcholine (SPC), which is produced from sphingomyelin by sphingomyelin deacylase, is increased. In the present study, weExpand
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Adhesiveness of β5 integrin variant lacking FNK767–769 is similar to that of the prototype containing FNKFNK764–769
Little is known about the functions of two different β5 integrins: repeated‐FNK (FNKFNK764–769) and single‐FNK (FNK764–766) amino acid sequences in the cytoplasmic domain. We examined whether theyExpand
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Involvement of leukotriene B4 in spontaneous itch‐related behaviour in NC mice with atopic dermatitis‐like skin lesions
Abstract:  To elucidate the mechanisms of severe itch in atopic dermatitis, we investigated the role of leukotriene B4, a potent itch mediator, in spontaneous itch‐related behaviour in NC mice withExpand
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Gene expression analysis of a Helicobacter pylori-infected and high-salt diet-treated mouse gastric tumor model: identification of CD177 as a novel prognostic factor in patients with gastric cancer
BackgroundHelicobacter pylori (H. pylori) infection and excessive salt intake are known as important risk factors for stomach cancer in humans. However, interactions of these two factors with geneExpand
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Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings
IntroductionThe periaqueductal gray matter (PAG) is considered to play an important role in generating migraine, but findings from imaging studies remain unclear. Therefore, we investigated whetherExpand
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Lymphocyte-proliferative responses to HIV antigens as a potential measure of immunological reconstitution in HIV disease.
Lymphocyte-proliferative responses (LPRs) to HIV antigens are absent or of low magnitude in the majority of HIV-infected individuals, even early in the disease. However, lymphocytes from 2% to 3% ofExpand
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Carotid plaque signal differences among four kinds of T1-weighted magnetic resonance imaging techniques: A histopathological correlation study
IntroductionSeveral magnetic resonance (MR) imaging techniques are used to examine atherosclerotic plaque of carotid arteries; however, the best technique for visualizing intraplaque characteristicsExpand
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Efficient synthesis of an optically active tetrahydrozerumbone exhibiting a fragrance and the application of zerumbone derivatives with a medium ring structure
Abstract ( R )-Tetrahydrozerumbone 2 , which has a powerful balmy fragrance, contains a stereogenic carbon at the C2 position and can be easily prepared from zerumbone 1 , one of the most importantExpand
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