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Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials.
TLDR
The easy-to-use nomograms can predict LR, DM, and OS over a 5-year period after surgery and may be used as decision support tools in future trials by using the three defined risk groups to select patients for postoperative chemotherapy and close follow-up. Expand
Adjuvant chemotherapy after preoperative (chemo)radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data.
TLDR
Overall, adjuvant fluorouracil-based chemotherapy did not improve overall survival, disease-free survival, or distant recurrences, but aduvant chemotherapy might benefit patients with a tumour 10-15 cm from the anal verge in terms of disease- free survival and distant recurrence. Expand
No benefit of adjuvant Fluorouracil Leucovorin chemotherapy after neoadjuvant chemoradiotherapy in locally advanced cancer of the rectum (LARC): Long term results of a randomized trial (I-CNR-RT).
TLDR
In patients with LARC treated with NACT-RT, the addition of ACT did not improve 5year OS and DFS and had no impact on the distant metastasis rate. Expand
Inter-observer variability of clinical target volume delineation in radiotherapy treatment of pancreatic cancer: a multi-institutional contouring experience
TLDR
The CV and mDSI obtained values for Elective CTVs showed an acceptable agreement among participants either in postoperative as well in preoperative setting, and additional strategies to reduce the variability in Boost CTV delineation need to be found and promoted. Expand
[18F]Choline PET/CT and stereotactic body radiotherapy on treatment decision making of oligometastatic prostate cancer patients: preliminary results
TLDR
Repeated salvage [18F]FMCHPET/CT-guided SBRT is well tolerated and could defer the beginning of systemic therapy in selected patients with oligometastatic PCa. Expand
Time to surgery and pathologic complete response after neoadjuvant chemoradiation in rectal cancer: A population study on 2094 patients
TLDR
A large population based analysis to evaluate pathologic response according to time of surgery for LARC patients treated with modern techniques of radiotherapy and surgery significantly improved the pathological response. Expand
Selection of appropriate end-points (pCR vs 2yDFS) for tailoring treatments with prediction models in locally advanced rectal cancer.
TLDR
Evaluating pathologic complete response and two-year disease-free survival for overall survival and their potential to be relevant intermediate endpoints to predict finds 2yDFS is a stronger predictor of OS than pCR. Expand
Image-guided Stereotactic Body Radiotherapy in Metastatic Prostate Cancer.
TLDR
IG-SBRT is safe and can be considered as a valid therapy in patients with metastatic prostate cancer requiring a long-lasting metastases control. Expand
[18F]Fluorocholine PET/CT-guided stereotactic body radiotherapy in patients with recurrent oligometastatic prostate cancer
TLDR
Based on the findings, [18F]FMCH PET/CT can identify oligometastatic prostate cancer patients suitable for SBRT, resulting in a systemic therapy-free survival of 39.1 months. Expand
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