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Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases
TLDR
A new family of highly conserved inositol-polyphosphate kinases that contain a newly identified, unique consensus sequence are identified. Expand
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
TLDR
This study shows that D2 receptors have a key role in the dopaminergic control of nervous function, using homologous recombination to generate D2-receptor-deficient mice, which have therapeutic potential as a model for investigating and correcting dysfunctions of the dopamine system. Expand
Abnormal Synaptic Plasticity in the Striatum of Mice Lacking Dopamine D2 Receptors
TLDR
This study indicates that D2Rs play a key role in mechanisms underlying the direction of long-term changes in synaptic efficacy in the striatum and shows that an imbalance between D2R and NMDA receptor activity induces altered synaptic plasticity at corticostriatal synapses. Expand
An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons
TLDR
Insight is provided into mRNA transport in axons and a new NGF-responsive localization element that directs the targeting and local translation of an axonal transcript is revealed. Expand
Influence of Inositol Pyrophosphates on Cellular Energy Dynamics
TLDR
It is shown that inositol pyrophosphates participate in the control of intracellular ATP concentration and control the activity of the major glycolytic transcription factor GCR1, and regulates ATP concentration by altering the gly colytic/mitochondrial metabolic ratio. Expand
Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains
TLDR
It is proposed that InsPs communicate cytosolic Pi levels to SPX domains and enable them to interact with a multitude of proteins to regulate Pi uptake, transport, and storage in fungi, plants, and animals. Expand
The Inositol Hexakisphosphate Kinase Family
TLDR
Synthesis of the diphosphorylated inositol phosphates is revealed to be more complex and interdependent than previously envisaged. Expand
Identification of an Evolutionarily Conserved Family of Inorganic Polyphosphate Endopolyphosphatases*
TLDR
It is shown that budding yeast mutants unable to produce inositol pyrophosphates have undetectable levels of poly-P, and it is proved that this is an evolutionarily conserved feature because mammalian Nudix hydrolase family members, the three Ddp1 homologues in human cells (DIPP1, DIPP2, and DIPP3), are also capable of degradingpoly-P. Expand
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
TLDR
The D2 receptor plays a crucial role in the motivational component of drug addiction, as mice lacking D2 receptors behaved the same as wild-type mice when food is used as reward. Expand
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event
TLDR
It is reported that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7) physiologically phosphorylates mammalian and yeast proteins, and this phosphate transfer reflects pyroph phosphorylation. Expand
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