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Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish
TLDR
The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory and an intra-species Y chromosome polymorphism representing-in real time-different stages of sex chromosome formation that display features of early mammalian XY evolution "in action" is uncovered. Expand
Redox‐dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana
TLDR
The hypothesis is tested that some heat stress transcription factors (HSFs) are activated after formation of inter‐ or intramolecular disulfide bonds and conserved cysteinyl residues in AtHSFA8 that might function as redox sensors in plants are identified. Expand
Parallel evolution of genes controlling mitonuclear balance in short‐lived annual fishes
TLDR
The pattern of positive selection in annual and nonannual African killifishes is investigated to identify a genomic substrate for evolution of annual life history (and reduced lifespan) and some genes under positive selection also in long‐lived mammals such as bats and mole‐rats are identified. Expand
FRAMA: from RNA-seq data to annotated mRNA assemblies
TLDR
A comparison with three different sources of naked mole-rat transcripts reveals that FRAMA’s gene models are better supported by RNA-seq data than any other transcript set, demonstrating the competitiveness of FRAMA to state of the art genome-based transcript reconstruction approaches. Expand
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan
TLDR
The results provide a meaningful resource for follow-up studies to mechanistically link identified genes and amino acids under positive selection to aging and lifespan determination, andemplary protein homology modeling suggests functional consequences for amino acid changes underpositive selection. Expand
PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes
TLDR
The software tool PosiGene is developed, which detects positively selected genes (PSGs) on genome-scale, allows analysis of specific evolutionary branches, can be used in arbitrary species contexts and offers visualization of the results for further manual validation and biological interpretation. Expand
Tissue-, sex-, and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin-like growth factor 2 imprinting control region.
TLDR
In-depth insight is provided into the complex DNA methylation changes of rat Nr3c1 and Igf2/H19 during aging that are tissue and sex specific and hence for vulnerability to stress- and age-associated diseases. Expand
Outgroups and Positive Selection: The Nothobranchius furzeri Case.
TLDR
The origin of positively selected sites in aging-related genes of the N. furzeri genome is determined using the recently sequenced turquoise killifish genome. Expand
Surprisingly long survival of premature conclusions about naked mole‐rat biology
TLDR
This work reviews 28 of these persistent myths about naked mole‐rat sensory abilities, ecophysiology, social behaviour, development and ageing, and where possible explains how these misunderstandings came about. Expand
Abundance and size of hyaluronan in naked mole-rat tissues and plasma
TLDR
NMR samples, contrary to expectations, do not harbor ultra-high molecular weight hyaluronan, although its amount and average molecular weight are higher in NMR than in guinea pig tissues and serum, and extremely high Hyal3 and Tnfaip6 expression may provide the NMR with a bespoke, and perhaps protective, HA metabolism. Expand
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