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Zinc induces thymulin secretion from human thymic epithelial cells in vitro and augments splenocyte and thymocyte responses in vivo.
TLDR
Preliminary experiments indicate that treatment with zinc may have immunotherapeutic relevance, particularly in the aged and stressed organism. Expand
Immunotherapy with natural interleukins and/or thymosin alpha 1 potently augments T-lymphocyte responses of hydrocortisone-treated aged mice.
TLDR
Data indicate that NCM and T alpha 1 alone and in combination may be therapeutically useful to restore T-lymphocyte number or function in secondary immunodeficiency. Expand
Potentiation of immune responses in mice by a new inosine derivative--methyl inosine monophosphate (MIMP).
TLDR
MIMP qualifies as an effective immunopotentiator in normal mice and increases in the responses of splenic lymphocytes to mitogen stimulation with phytohemagglutinin (PHA) and concanavalin A (Con A) were observed under similar conditions of MIMP treatment. Expand
Immunopharmacologic Properties of Inosine 5'‐Methyl Monophosphate (MIMP)
Immunopotentiating activity of a nucleotide derivative, heptaminol AMP amidate (HAA) in mice and spontaneously hypertensive rats (SHR).
TLDR
In spontaneously hypertensive rats, with a state of immunosuppression, 10 days consecutive administrations of HAA at the dose of 10 mg/kg was found to increase significantly the anti-SRBC PFC and antibody titer values. Expand
Effect of heptaminol AMP amidate, a new nucleotide derivative, on in vitro humoral immunity.
TLDR
The present results suggested that HAA-mediated immunopotentiation might be in some way related to the intracellular level of cyclic nucleotides in the early phase of culture. Expand
Comparisons of heptaminol AMP amidate and dibutyryl cyclic AMP on murine splenocytes proliferation.
TLDR
The pattern of inhibition of mitogen-induced responses by HAA at higher concentrations was found to be almost similar to that of dibutyryl cyclic AMP (DbcAMP). Expand
Effects of heptaminol AMP amidate on suppressor and helper function of murine T cells.
TLDR
The present results suggested that HAA-mediated immunopotentiation was possible by a combined suppressive effect on Ts cells and enhancing effect on Th cells. Expand
Cytokine Synergy in Immunotherapy
TLDR
This chapter will be the intent of this chapter to summarize recent efforts to employ combination therapy to restore and direct the thymus-dependent T cell system. Expand
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