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Stability and structural features of DNA intercalation with ethidium bromide, acridine orange and methylene blue
Abstract Ethidium bromide (EB), acridine orange (AO), methylene blue (MB) and other fluorescent compounds are often used to probe DNA structure in drug–DNA and protein–DNA interactions. They bindExpand
A comprehensive review on tyrosinase inhibitors
This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades. Expand
Interaction study of pioglitazone with albumin by fluorescence spectroscopy and molecular docking.
Hydrogen bonding was found to play a major role in the interaction of pioglitazone with HSA and piog litazone have an ability to quench the intrinsic fluorescence of HSA tryptophan through a static quenching procedure. Expand
Enzyme inhibition and activation: A general theory
The rate of an enzymatic reaction may be changed by a moderator. Usually, the effect is to reduce the rate, and this is called inhibition. Sometimes the rate of enzyme reaction is raised, and this isExpand
Formation of the molten globule-like state during prolonged glycation of human serum albumin.
The results suggest that in acute diabetes mellitus patients, HSA, after 21 days of glycation, passes through a molten globule-like state and may contribute to the pathogenesis of diabetes, and perhaps other diseases. Expand
A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin
This review surveyed the role of furin cleavage site (FCS) on the life cycle of the CoV and discussed that the small molecular inhibitors can limit the interaction of ACE-2 and furin with SP and can be used as potential therapeutic platforms to combat the spreading CoV epidemic. Expand
Analysis of Binding Interaction of Curcumin and Diacetylcurcumin with Human and Bovine Serum Albumin Using Fluorescence and Circular Dichroism Spectroscopy
The visible CD spectra indicated that the optical activity observed during the ligand binding due to induced-protein chirality suggested the important role of the phenolic OH group of CUR in the binding process. Expand
Interaction of single and multi wall carbon nanotubes with the biological systems: tau protein and PC12 cells as targets
It is suggested that surface tension may be used to determine how nanoparticle structure affects neurotoxicity and protein conformational changes. Expand
Biological activity of camel milk casein following enzymatic digestion.
The results of this study suggest that when camel milk is consumed and digested, the produced peptides start to act as natural antioxidants and ACE-inhibitors. Expand
The shapes of Scatchard plots for systems with two sets of binding sites
Introduction One of the most familiar and important processes in biochemistry is the reversible combination of small ions or molecules with specific sites on the surface of a protein or otherExpand