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- Publications
- Influence
Oral contraceptives reduce lamotrigine plasma levels
- A. Sabers, I. Öhman, J. Christensen, T. Tomson
- Medicine
- Neurology
- 26 August 2003
The mean steady-state plasma concentration of lamotrigine (LTG) was 13 μmol/L in 22 women taking LTG in combination oral contraceptives (OC) compared with 28 μmol/L among 30 women on LTG who did not… Expand
Oral Contraceptives Induce Lamotrigine Metabolism: Evidence from a Double‐blind, Placebo‐controlled Trial
- J. Christensen, Vaiva Petrenaite, +4 authors A. Sabers
- Medicine
- Epilepsia
- 1 March 2007
Summary: Purpose: This study evaluates the effect of oral contraceptives on lamotrigine (LTG) plasma concentrations and urine excretion of LTG metabolites in a double‐blind, placebo‐controlled,… Expand
Lamotrigine plasma levels reduced by oral contraceptives
- A. Sabers, J. Buchholt, P. Uldall, E. Hansen
- Medicine
- Epilepsy Research
- 1 November 2001
Although it is known that the use of oral contraceptives (OC's) can induce glucuronide conjugating enzymes, currently no data exists as to the potential that the elimination of the glucuronidated… Expand
Dose-dependent teratogenicity of valproate in mono- and polytherapy
- T. Tomson, D. Battino, +6 authors F. Vajda
- Medicine
- Neurology
- 8 September 2015
Objective: To assess the risk of major congenital malformations (MCMs) in association with maternal use of valproic acid (VPA) in monotherapy or adjunctive therapy, and its relationship with dose.… Expand
EURAP: An International Registry of Antiepileptic Drugs and Pregnancy
- T. Tomson, D. Battino, +5 authors F. Vajda
- Medicine
- Epilepsia
- 1 November 2004
Editor’s note—Several pregnancy registries presently are collecting data on pregnancy outcomes in women with epilepsy. Such registries have inherent limitations of selection bias and incomplete… Expand
Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations
- A. Reimers, E. Brodtkorb, A. Sabers
- Medicine
- Seizure
- 1 May 2015
Antiepileptic drugs (AEDs) and hormonal contraceptives may affect each other's metabolism and clinical efficacy. Loss of seizure control and unplanned pregnancy may occur when these compounds are… Expand
Newer anticonvulsants: comparative review of drug interactions and adverse effects.
The tolerability and drug interaction profiles of 6 new anticonvulsants: oxcarbazepine, vigabatrin, lamotrigine, gabapentin, tiagabine and topiramate, are reviewed. In general, these new… Expand
Epilepsy and risk of death and sudden unexpected death in the young: A nationwide study
- A. Holst, B. G. Winkel, +6 authors J. Tfelt-Hansen
- Medicine
- Epilepsia
- 1 September 2013
Patients with epilepsy are at increased risk of premature death from all causes and likely also from sudden unexplained death (SUD). Many patients with epilepsy have significant comorbidity, and it… Expand
Seizure control and treatment changes in pregnancy: Observations from the EURAP epilepsy pregnancy registry
- D. Battino, T. Tomson, +5 authors F. Vajda
- Medicine
- Epilepsia
- 1 September 2013
To analyze seizure control, dose adjustments, and other changes of antiepileptic drug (AED) treatment during pregnancy in a large cohort of women with epilepsy entering pregnancy on monotherapy with… Expand
Pharmacology of vigabatrin.
Vigabatrin (gamma-vinyl GABA) is a relatively new antiepileptic drug. Vigabatrin increases the concentration of gamma-aminobutyric acid (GABA) in the brain by inhibiting the major GABA metabolizing… Expand