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Oral contraceptives reduce lamotrigine plasma levels
The mean steady-state plasma concentration of lamotrigine (LTG) was 13 μmol/L in 22 women taking LTG in combination oral contraceptives (OC) compared with 28 μmol/L among 30 women on LTG who did notExpand
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Oral Contraceptives Induce Lamotrigine Metabolism: Evidence from a Double‐blind, Placebo‐controlled Trial
Summary:  Purpose: This study evaluates the effect of oral contraceptives on lamotrigine (LTG) plasma concentrations and urine excretion of LTG metabolites in a double‐blind, placebo‐controlled,Expand
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Lamotrigine plasma levels reduced by oral contraceptives
Although it is known that the use of oral contraceptives (OC's) can induce glucuronide conjugating enzymes, currently no data exists as to the potential that the elimination of the glucuronidatedExpand
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Dose-dependent teratogenicity of valproate in mono- and polytherapy
Objective: To assess the risk of major congenital malformations (MCMs) in association with maternal use of valproic acid (VPA) in monotherapy or adjunctive therapy, and its relationship with dose.Expand
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EURAP: An International Registry of Antiepileptic Drugs and Pregnancy
Editor’s note—Several pregnancy registries presently are collecting data on pregnancy outcomes in women with epilepsy. Such registries have inherent limitations of selection bias and incompleteExpand
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Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations
Antiepileptic drugs (AEDs) and hormonal contraceptives may affect each other's metabolism and clinical efficacy. Loss of seizure control and unplanned pregnancy may occur when these compounds areExpand
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Newer anticonvulsants: comparative review of drug interactions and adverse effects.
The tolerability and drug interaction profiles of 6 new anticonvulsants: oxcarbazepine, vigabatrin, lamotrigine, gabapentin, tiagabine and topiramate, are reviewed. In general, these newExpand
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Epilepsy and risk of death and sudden unexpected death in the young: A nationwide study
Patients with epilepsy are at increased risk of premature death from all causes and likely also from sudden unexplained death (SUD). Many patients with epilepsy have significant comorbidity, and itExpand
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Seizure control and treatment changes in pregnancy: Observations from the EURAP epilepsy pregnancy registry
To analyze seizure control, dose adjustments, and other changes of antiepileptic drug (AED) treatment during pregnancy in a large cohort of women with epilepsy entering pregnancy on monotherapy withExpand
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Pharmacology of vigabatrin.
Vigabatrin (gamma-vinyl GABA) is a relatively new antiepileptic drug. Vigabatrin increases the concentration of gamma-aminobutyric acid (GABA) in the brain by inhibiting the major GABA metabolizingExpand
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