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Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.
Repair of DNA double strand breaks (DSBs) plays a critical role in the maintenance of the genome. DSB arise frequently as a consequence of replication fork stalling and also due to the attack ofExpand
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FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
In response to DNA damage or replication fork stress, the Fanconi anemia pathway is activated, leading to monoubiquitination of FANCD2 and FANCI and their colocalization in foci. Here we show that,Expand
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Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.
Cross-linking agents that induce DNA interstrand cross-links (ICL) are widely used in anticancer chemotherapy. Yeast genetic studies show that nucleotide excision repair (NER), Rad6/Rad18-dependentExpand
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An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells
In vertebrates Cdk1 is required to initiate mitosis; however, any functionality of this kinase during S phase remains unclear. To investigate this, we generated chicken DT40 mutants, in which anExpand
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Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
Parp‐1 and Parp‐2 are activated by DNA breaks and have been implicated in the repair of DNA single‐strand breaks (SSB). Their involvement in double‐strand break (DSB) repair mediated by homologousExpand
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RAD18 and Poly(ADP-Ribose) Polymerase Independently Suppress the Access of Nonhomologous End Joining to Double-Strand Breaks and Facilitate Homologous Recombination-Mediated Repair
ABSTRACT The Saccharomyces cerevisiae RAD18 gene is essential for postreplication repair but is not required for homologous recombination (HR), which is the major double-strand break (DSB) repairExpand
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Cytogenetic analysis in lymphocytes from radiation workers exposed to low level of ionizing radiation in radiotherapy, CT-scan and angiocardiography units.
Ionizing radiation is known as a classical mutagen capable of inducing various kinds of stable and unstable chromosomal aberrations. The percentage of cells with chromosomal aberrations was analyzedExpand
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The 9-1-1 DNA Clamp Is Required for Immunoglobulin Gene Conversion
ABSTRACT Chicken DT40 cells deficient in the 9-1-1 checkpoint clamp exhibit hypersensitivity to a variety of DNA-damaging agents. Although recent work suggests that, in addition to its role inExpand
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Gold nanoparticles in combination with megavoltage radiation energy increased radiosensitization and apoptosis in colon cancer HT-29 cells
Abstract Purpose: Gold nanoparticles (GNP) act as a radiosensitizer in radiation therapy. However, recent studies have shown contradictory evidence in terms of radiosensitization in the presence ofExpand
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A First Report of Hb Alesha [β67(E11)Val>Met, GTG>ATG] in an Iranian Patient
Background: Hemoglobin (Hb) Alesha is a rare and very unstable Hb variant, resulting in disruption of the heme pocket and producing severe hemolysis in heterozygous statues. In this study, weExpand
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