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Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents
- M. Field, R. Oles, A. S. Lewis, S. McCleary, J. Hughes, L. Singh
- British journal of pharmacology
- 1 August 1997
1 Gabapentin (neurontin) is a novel antiepileptic agent that binds to the α2δ subunit of voltage‐dependent calcium channels. The only other compound known to possess affinity for this recognition… Expand
Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.
- L. Singh, A. S. Lewis, M. Field, J. Hughes, G. Woodruff
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 15 February 1991
The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective CCK-B receptor antagonists CI-988 (PD… Expand
Comparison of venous and capillary blood sampling for the clinical determination of tobramycin serum concentrations.
- A. S. Lewis, G. Taylor, H. O. Williams, M. Lewis
- Biology, Medicine
- British journal of clinical pharmacology
- 1 December 1985
Tobramycin concentrations have been determined in serum from capillary, venous and arterial blood samples taken from 16 patients during and after surgery. In 73 paired samples the concentrations in… Expand
Modified enzyme immunoassays for tobramycin using reduced sample and reagent volumes.
- A. S. Lewis, G. Taylor, H. Rowe, H. O. Williams, M. Lewis
- Chemistry, Medicine
- American journal of hospital pharmacy
- 1 March 1987
The accuracy of two modified enzyme immunoassay (EMIT) methods using reduced sample and reagent volumes for determining serum tobramycin concentrations was compared with that of the standard method.… Expand
Eliminating oxygen supply limitations for transplanted microencapsulated islets in the treatment of type 1 diabetes
- A. S. Lewis
Evidence foraninvolvement ofthebrain cholecystokinin B receptor inanxiety
ABSTRACT The effect of neuropeptide cholecystokinin(CCK)receptor agonists andantagonists wasexaminedintherat elevated X-maze model of anxiety. The selective CCK-Breceptor antagonists CI-988 (PD… Expand