Share This Author
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.
- E. De Clercq, J. Descamps, P. De Somer, P. Barr, A. S. Jones, R. T. Walker
- BiologyProceedings of the National Academy of Sciences…
- 1 June 1979
In animal model systems (namely, cutaneous herpes infections of athymic nude mice), (E)-5-(2-bromovinyl)-dUrd suppressed the development of herpetic skin lesions and mortality therewith associated, whether the compound was administered topically or systemically.
Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus.
A large variety of antiherpes compounds was compared for their inhibitory activity against laboratory strains and clinical isolates of herpes simplex virus (HSV) type 1 and type 2, suggesting that phosphorylation by virus-induced TK was required to produce specific inhibition of HSV replication.
Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins.
The relative affinities of these compounds for the virus-induced dThd kinase correlated closely with their inhibitory effects on these viruses, suggesting that the selectivity of E-5-(2-bromovinyl)-dUrd and its congeners toward herpes viruses (HSV and VZV) is to a large extent dependent on their phosphorylation by the virus.
Use of Alkyltrimethylammonium Bromides for the Isolation of Ribo- and Deoxribo-nucleic Acids
- A. S. Jones
- Chemistry, BiologyNature
- 20 July 1963
A change in the nature of this material and modifications to the procedure used for the isolation of nucleic acids have necessitated a re-examination of the method.
The synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine-related compounds
The isolation of bacterial nucleic acids using cetyltrimethylammonium bromide (cetavlon).
- A. S. Jones
- Biology, ChemistryBiochimica et biophysica acta
The synthesis of the potent anti-herpes virus agent, E-5(2-bromovinyl)-2′-deoxyuridine and related compounds
Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.
- S. Farrow, A. S. Jones, A. Kumar, R. T. Walker, J. Balzarini, E. De Clercq
- ChemistryJournal of medicinal chemistry
- 1 May 1990
Their antiviral spectrum and potency was remarkably similar to that of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and 9-[(2-hydroxyethoxy)-methyl]guanine (ACV), suggesting that they only act as prodrugs of BVDU and ACV, respectively.
761. Glycosylureas. Part I. Preparation and some reactions of D-glucosylureas and D-ribosylureas
The action of alkali on some pyrimidines and their derivatives
On treatment of purines and their nucleosides and nucleotides with N-alkali at 100° for 1 hr., three types of reaction occurred: (1) opening of the imidazole ring to give finally a derivative of…