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SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells
TLDR
It is suggested that SMEDWI-2 functions within dividing neoblasts to support the generation of cells that promote regeneration and homeostasis. Expand
β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis
TLDR
It is suggested that β-catenin functions as a molecular switch to specify and maintain anteroposterior identity during regeneration and homeostasis in planarians. Expand
Bridging the regeneration gap: genetic insights from diverse animal models
TLDR
This work has begun to delineate differences and similarities in the regenerative capabilities and mechanisms among diverse animal species, and to address some of the key questions about the molecular and cell biology of regeneration. Expand
SmedGD: the Schmidtea mediterranea genome database
TLDR
The planarian Schmidtea mediterranea Genome Database (SmedGD) integrates in a single web-accessible portal all available data associated with the planarian genome, including predicted and annotated genes, ESTs, protein homologies, gene expression patterns and RNAi phenotypes. Expand
Regeneration in the metazoans: why does it happen?
TLDR
This essay will review the distribution and the modes of regeneration that are found in the different metazoan phyla, and re-examine ideas on its evolutionary origins, and discuss its possible relationship to both asexual reproduction and embryogenesis. Expand
The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration
TLDR
The characterization of ∼3000 non-redundant cDNAs from a clonal line of the planarian Schmidtea mediterranea, and the ability of abrogating gene expression in planarians using RNA interference technology, pave the way for a systematic study of the remarkable biological properties displayed by Platyhelminthes. Expand
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians
TLDR
The identification and characterization of nou-darake (ndk), a gene encoding a fibroblast growth factor receptor (FGFR)-like molecule specifically expressed in the head region of the planarian Dugesia japonica, and the data suggest that ndk may modulate FGF signalling in stem cells to restrict brain tissues to theHead region of planarians. Expand
Planarian Regeneration: Its End Is Its Beginning
TLDR
An unlikely model animal, the planarian Schmidtea mediterranea, is proving valuable in this endeavor to dissect the genetics, cell biology, and physiological aspects that make regeneration possible. Expand
Centrosome Loss in the Evolution of Planarians
TLDR
This study uncovers the molecular architecture and evolution of the animal centrosome and emphasizes the plasticity of animal cell biology and development. Expand
High-resolution profiling and discovery of planarian small RNAs
TLDR
The first comprehensive small RNA analysis in animals belonging to the third animal superphylum, the Lophotrochozoa, is presented, and a number of miRNAs that may function in regeneration are single out. Expand
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