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Metabolic oxidation regulates embryonic stem cell differentiation
TLDR
It is demonstrated that the stem cell redox status is regulated during differentiation and postulate that the highly unsaturated metabolome sustained by stem cells makes them particularly attuned to differentiate in response to in vivo oxidative processes such as inflammation.
PHEREXA: A phase III study of trastuzumab (H) + capecitabine (X) ± pertuzumab (P) for patients (pts) who progressed during/after one line of H-based therapy in the HER2-positive metastatic breast
TLDR
The primary endpoint was independent review facility-assessed PFS (IRF PFS), and the secondary endpoints of OS and safety are also reported.
Dima assoi Pérez Arcas 1872 (Coleoptera: Elateridae): from montane to hypogean life. An example of exaptations to the subterranean environment?
Summary The mesovoid shallow substratum (MSS) of two areas in the Moncayo Massif (Zaragoza, Spain) was sampled for a year with subterranean pitfall traps installed at one meter depth in stony debris.
Aggregation-Induced Emission Properties in Fully π-Conjugated Polymers, Dendrimers, and Oligomers
TLDR
This review focuses on selected fully conjugated oligomers, dendrimers and polymers, and briefly summarize their synthetic routes, fluorescence properties and potential applications.
MALDI-TOF mass spectrometric analysis of enzyme activity and lectin trapping on an array of N-glycans.
TLDR
A novel strategy for the surface-based MALDI-TOF analysis of glycan arrays that is conceptually a fusion of the approaches of Wong, Siuzdak, Mrksich, and their respective co-workers is presented.
A highly stereoselective synthesis of glycidic amides based on a new class of chiral sulfonium salts: applications in asymmetric synthesis.
TLDR
A new type of chiral sulfonium salts that are characterized by a bicyclic system has been designed and synthesized from α-amino acids and were reduced into their corresponding epoxy alcohols and subjected to oxirane-ring-opening reactions with different types of nucleophiles.
Total synthesis of Bengamide E and analogues by modification at C-2 and at terminal olefinic positions.
TLDR
These studies demonstrate the validity of the synthetic strategy, although they reveal some problems associated with the olefin cross metathesis, whose efficiency depends on the substituent at the C-2 position as well as the steric environment of the alkene.
Chiral sulfur ylides for the synthesis of bengamide E and analogues.
TLDR
A new synthetic methodology of asymmetric epoxidation developed in the laboratories has been employed for the stereoselective synthesis of bengamide E and analogues at the terminal olefinic position and allowed access to the generation of a wide array of new bENGamide analogues.
Exploring the Ring-Closing Metathesis for the Construction of the Solomonamide Macrocyclic Core: Identification of Bioactive Precursors.
TLDR
Preliminary biological evaluations of the generated solomonamide precursors revealed antitumor activity against various tumor cell lines and the olefin metathesis reaction demonstrated efficiency and validity for the construction of the macrocyclic core.
Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins.
TLDR
A rapid method for qualitative label-free detection of carbohydrate-protein interactions on arrays of simple synthetic glycans, more complex natural glycosaminoglycans (GAG), and lectins/carbohydrate binding proteins using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.
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