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Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2.
TLDR
The results indicate that the active oxygen species primarily responsible for photoinduced DNA cleavage by C(60) under physiological conditions are reduced species such as O(2)(-)* and *OH. Expand
Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents.
TLDR
The data suggested that the phototoxicity of the new quinolones was related to DNA damage caused by reactive oxygen species, especially 1O2. Expand
Comparison of Singlet Oxygen Production Efficiency of C60 with Other Photosensitizers, Based on 1268 nm Emission.
Singlet oxygen generation from laser-excited C60 was measured directly by using a sensitive near-infrared emission spectrometer to monitor the O2(1Δg)→O2(3Σg-) transition at 1268nm. The emissionExpand
SINGLET OXYGEN PRODUCTION FROM FULLERENE DERIVATIVES : EFFECT OF SEQUENTIAL FUNCTIONALIZATION OF THE FULLERENE CORE
Singlet oxygen production efficiency of several laser-excited fullerene derivatives is compared by measuring the 1268 nm emissions; the efficiency was independent of the kind of addends, but itExpand
In vitro degradation of tropoelastin by reactive oxygen species
TLDR
ROS may play a degradative role in elastin metabolism which may cause the elastolytic changes or the deposition of fragmented elastic fibers in photoaged skin or age-related elastoytic disorders. Expand
Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen.
TLDR
It is found that topical application of squalene peroxide induced skin hyperpigmentation through increasing prostaglandin E(2) release from keratinocytes in guinea pigs, suggesting that squalenes peroxide formation by singlet oxygen plays a key role in photo-induced skin damage. Expand
In Vitro Alternatives and Phototoxicity Testing. I. Evaluation of In Vitro Phototoxicity Assays
Three in vitro phototoxicity assays — the photohaemolysis assay, the haemoglobin (Hb) photo-oxidation assay, and the 3T3 cell neutral red uptake phototoxicity (3T3 NRU PT) assay — were evaluated forExpand
Singlet Oxygen (1Δg) Generation from Coproporphyrin inPropionibacterium acneson Irradiation
Abstract Although singlet oxygen has been postulated to be a highly reactive and toxic intermediate, there has been no evidence of considerable generation of singlet oxygenin vivolevel except forExpand
Singlet oxygen (1 delta g) generation from coproporphyrin in Propionibacterium acnes on irradiation.
TLDR
It is suggested that singlet oxygen can be generated on the skin surface from P. acnes porphyrin under ultraviolet irradiation and induce serious damage to the skin. Expand
Cross-linking of collagen by singlet oxygen generated with UV-A.
TLDR
The finding that semicarbazide inhibited cross-linking of collagen showed that cross-links were formed between photooxidized histidyl residues and amino groups, suggesting that singlet oxygen generated by UV-A irradiation may contribute to cross-link of collagen in the process of skin photoaging. Expand
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