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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
Hypertrophic chondrocytes in the epiphyseal growth plate express the angiogenic protein vascular endothelial growth factor (VEGF). To determine the role of VEGF in endochondral bone formation, weExpand
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Activating Smoothened mutations in sporadic basal-cell carcinoma
Basal-cell carcinomas (BCCs) are the commonest human cancer. Insight into their genesis came from identification of mutations in the PATCHED gene (PTCH) in patients with the basal-cell nevusExpand
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Renal and neuronal abnormalities in mice lacking GDNF
GLIAL cell-line derived neurotrophic factor (GDNF) is a potent survival factor for embryonic midbrain dopaminergic1, spinal motor2, cranial sensory3, sympathetic, and hindbrain noradrenergic4Expand
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GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney
Glial cell line-derived neurotrophic factor (GDNF) is a distant member of the TGFbeta protein family that is essential for neuronal survival and renal morphogenesis. We show that mice who areExpand
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  • Open Access
VEGF is required for growth and survival in neonatal mice.
We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP- mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGFExpand
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Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog.
Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to the two known human IL-8 receptors wasExpand
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A genetic linkage map of the bovine genome
A cattle genetic linkage map was constructed which marks about 90% of the expected length of the cattle genome. Over 200 DNA polymorphisms were genotyped in cattle families which comprise 295Expand
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Comparisons of the Intraocular Tissue Distribution, Pharmacokinetics, and Safety of 125I-Labeled Full-Length and Fab Antibodies in Rhesus Monkeys Following Intravitreal Administration
Access of recombinant proteins to the retina following intravitreal administration is poorly understood. A study was conducted in male Rhesus monkeys (15 to 28 mo of age; 2.8-3.3 kg) in order toExpand
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The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor
The orphan receptor CRF2-4 is a member of the class II cytokine receptor family (CRF2), which includes the interferon receptors, the interleukin (IL) 10 receptor, and tissue factor. CRFB4, the geneExpand
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Immunohistochemical Localization of Phosphodiesterase 10A in Multiple Mammalian Species
A monoclonal antibody directed against the amino terminal of rat phosphodiesterase 10A (PDE10A) was used to localize PDE10A in multiple central nervous system (CNS) and peripheral tissues from mouse,Expand
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