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Aging and intellectual disability: insights from mouse models of Down syndrome.
Down syndrome (DS) is one of many causes of intellectual disability (ID), others including but not limited to, fetal alcohol syndrome, Fragile X syndrome, Rett syndrome, Williams syndrome, hypoxia,Expand
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Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome
Down syndrome (DS) is a multi-faceted condition resulting in the most common genetic form of intellectual disability. Mouse models of DS, especially the Ts65Dn model, have been pivotal in furtheringExpand
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Mouse Models of Aneuploidy
Abnormalities of chromosome copy number are called aneuploidies and make up a large health load on the human population. Many aneuploidies are lethal because the resulting abnormal gene dosage isExpand
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Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21
Chromosome copy number aberrations, anueploidies, are common in the human population but generally lethal. However, trisomy of human chromosome 21 is compatible with life and people born with thisExpand
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Axonal transport in a panel of mice that model Down syndrome.