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Amino acid derivatives from the marine sponge Jaspis digonoxea.
TLDR
Six heterocycles, previously unreported from marine origin have been isolated from the South African sponge Jaspis digonoxea and the novel digonazole was elucidated primarily by nmr spectroscopy.
Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species.
As part of a search for novel inhibitors of humandeficiency virus type 1 (HIV-1) reverse transcriptase (RT), the MeOH-EtOAc extract of a Red Sea sponge, Clathria sp., was shown to be active.
Nuttingins A-F and malonganenones D-H, tetraprenylated alkaloids from the Tanzanian gorgonian Euplexaura nuttingi.
TLDR
Six new tetraprenylated purine alkaloids, designated nuttingins A-F (1-6) and malonganenones D-G (7-10) displayed inhibitory activity against both K562 and UT7 tumor cell lines, compounds 3-5 being the most active ones, approximately 3-fold more potent than the others.
Mode of inhibition of HIV-1 reverse transcriptase by polyacetylenetriol, a novel inhibitor of RNA- and DNA-directed DNA polymerases.
TLDR
The inhibitor may alter the optimal stereochemistry of the polymerase active site relative to the primer terminus, bound dNTP and the metal ions that are crucial for efficient catalysis or, alternatively, may interfere with the thumb sub-domain movement and, thus, with the translocation of the primer-template following nucleotide incorporation.
Didmolamide A and B, two new cyclic hexapeptides from the marine ascidian Didemnum molle.
TLDR
Two novel cyclic hexapeptides, didmolamides A and B, were isolated from the compound ascidian Didemnum molle collected in Madagascar and the absolute configuration of all amino acids was determined to be l using Marfey's method for HPLC.
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