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Dietary intake estimate for perfluorooctanesulphonic acid (PFOS) and other perfluorocompounds (PFCs) in UK retail foods following determination using standard addition LC–MS/MS
The analysis of 252 food samples (UK-produced and imported) purchased from a variety of retail outlets in the UK was undertaken for the presence of perfluorooctanesulphonic acid (PFOS),Expand
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Staphyloferrin A as siderophore-component in fluoroquinolone-based Trojan horse antibiotics.
A series of fluoroquinolone conjugates was synthesised by linking the carboxylic acid functionality of the carboxylate-type siderophore staphyloferrin A and its derivatives to the piperazinylExpand
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Synthesis of citrate-ciprofloxacin conjugates.
Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined.Expand
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Probing linker design in citric acid-ciprofloxacin conjugates.
A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities.Expand
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Synthesis, Bioactivation and Anti-HIV Activity of 4-Acyloxybenzyl bis(Nucleosid-5′-yl) Phosphates
Abstract 4-Acyloxybenzyl bis(nucleosid-5′-yl) phosphates 7a-c and 9a-c were prepared as potential prodrugs of the anti-HIV nucleosides 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxyinosine (ddI)Expand
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The use of a dithiane protected benzoin photolabile safety catch linker for solid-phase synthesis
Abstract The dithiane protected benzoin group is shown to be a useful safety catch photolabile linker in solid-phase synthesis. Methods for the synthesis, loading, deprotection and photolysis of theExpand
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Mass spectral studies towards more reliable measurement of perfluorooctanesulfonic acid and other perfluorinated chemicals (PFCs) in food matrices using liquid chromatography/tandem mass spectrometry.
Liquid chromatography/mass spectrometry (LC/MS) experiments are described, leading to a reliable method for the measurement of perfluorooctanesulfonic acid (PFOS) and other perfluorinated chemicalsExpand
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Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support
Abstract Solid phase intramolecular Heck coupling allows the synthesis of 2-oxindoles. Additional diversity is introduced into the molecule by reductive alkylation prior to the Heck cyclisation andExpand
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Chemical and Biological Aspects of Nutritional Immunity-Perspectives for New Anti-Infectives that Target Iron Uptake Systems.
Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria haveExpand
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