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Synthesis of tetrazole fused azepanes and quantum chemical topology study on the mechanism of the intramolecular cycloaddition reaction
The synthesis of novel tetrazolo azepanes from azido nitriles by 1,3 intramolecular dipolar cycloaddition starting from monosaccharide derivatives is described. A quantum chemical topological study
Exploring the chemistry of epoxy amides for the synthesis of the 2''-epi-diazepanone core of liposidomycins and caprazamycins.
Two different strategies were shown to be efficient in constructing the diazepanone ring system: a reductive amination of an epoxy aldehyde with N-methylamine with subsequent intramolecular oxirane ring opening and a carbene insertion reaction of an acyclic diazoamine precursor.
Epoxy carbohydrate derivatives and analogues as useful intermediates in the synthesis of glycosidase inhibitors
This review collects a number of syntheses that target different sugar derivatives belonging to the principal families of glycosidase inhibitors, of which epoxide derivatives are key precursors.
Advances in the synthesis of calystegines and related products and their biochemical properties.
The revision of the structures and properties of Calystegines shows that they can be regarded as carbohydrate mimics, with related biological activities and peculiar characteristics. Not only they
Intramolecular [3+2] cycloaddition of azido-unsaturated esters derived of monosaccharides
St stereoselective methods for synthesizing iminosugars from 2,3-epoxyamides obtained from monosaccharides are developed and a theoretical DFT based study of the cycloaddition is conducted to value the probability of formation of the triazoline 4a and subsequent aromatization to triazole 1, versus elimination to the unsaturated ester 5.