A. Romano

Publications33
h-index18
Citations750
Highly Influential Citations23
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Antifungal lipopeptides from Bacillus amyloliquefaciens strain BO7.
TLDR
Three new lipopeptides were isolated from the organic extract of Bacillus amyloliquefaciens strain (BO7) and displayed strong and dose-dependent antifungal activity against the plant pathogenic fungus Fusarium oxysporum.
Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.
TLDR
The application of an inverse virtual screening in silico approach to natural bioactive molecules to screen their efficacy against proteins involved in cancer processes may facilitate the prediction of the activity of unknown ligands for known targets involved in the development of cancer.
Antifungal cyclic lipopeptides from Bacillus amyloliquefaciens strain BO5A.
TLDR
Two new cyclic lipopeptides, members of the surfactins family, were isolated and tested for their inhibitory activity against the four pathogenic fungi Fusarium oxysporum, Aspergillus niger, Botrytis cinerea, and Penicillium italicum and the biocontrol fungus Trichoderma harzianum.
Antifungal saponins from bulbs of white onion, Allium cepa L.
Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials.
The new endoperoxyketal polyketides manadoperoxides A-D (2-5) have been isolated from the Indonesian sponge Plakortis cfr. simplex and their stereostructures established by means of spectroscopic…
Role of new bacterial surfactins in the antifungal interaction between Bacillus amyloliquefaciens and Fusarium oxysporum
TLDR
Results suggest that the fungal cell wall might have a key role in the sensitivity of Fol towards bacterial surfactins from B. amyloliquefaciens, and mutants altered in cell wall structure showed increased sensitivity to the bacterial compounds.
Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents.
TLDR
Results obtained confirmed the crucial role of the cycloperoxide functionality, and revealed other structural features critical for antimalarial activity, namely the "Western" alkyl side chain, the dioxane ring conformation, and the absolute configuration of the stereogenic carbons on the 1,2-doxane ring, when affecting the bioactive ring conformed.
Polyacetylenes from Sardinian Oenanthe fistulosa: A Molecular Clue to risus sardonicus
TLDR
Oenanthotoxin and dihydrooenanthot toxin were found to potently block GABAergic responses, providing a molecular rationale for the symptoms of poisoning from water-dropwort (Oenanthe crocata) and related plants.
Structural characterization of tetranortriterpenes from Pseudrocedrela kotschyi and Trichilia emetica and study of their activity towards the chaperone Hsp90.
Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase I activity.
TLDR
Bioactivity-guided fractionation of the leaf methanolic extract of P. peltata, using the brine shrimp lethality test, led to the isolation of catechol derivative 4-nerolidylcatechol (4-NC), suggesting that this could be a possible mechanism for the cytotoxicity observed in KB cells.
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