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Antifungal lipopeptides from Bacillus amyloliquefaciens strain BO7.
Three new lipopeptides were isolated from the organic extract of Bacillus amyloliquefaciens strain (BO7) and displayed strong and dose-dependent antifungal activity against the plant pathogenic fungus Fusarium oxysporum.
Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.
The application of an inverse virtual screening in silico approach to natural bioactive molecules to screen their efficacy against proteins involved in cancer processes may facilitate the prediction of the activity of unknown ligands for known targets involved in the development of cancer.
Antifungal cyclic lipopeptides from Bacillus amyloliquefaciens strain BO5A.
Two new cyclic lipopeptides, members of the surfactins family, were isolated and tested for their inhibitory activity against the four pathogenic fungi Fusarium oxysporum, Aspergillus niger, Botrytis cinerea, and Penicillium italicum and the biocontrol fungus Trichoderma harzianum.
Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials.
The new endoperoxyketal polyketides manadoperoxides A-D (2-5) have been isolated from the Indonesian sponge Plakortis cfr. simplex and their stereostructures established by means of spectroscopic
Role of new bacterial surfactins in the antifungal interaction between Bacillus amyloliquefaciens and Fusarium oxysporum
Results suggest that the fungal cell wall might have a key role in the sensitivity of Fol towards bacterial surfactins from B. amyloliquefaciens, and mutants altered in cell wall structure showed increased sensitivity to the bacterial compounds.
Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents.
Results obtained confirmed the crucial role of the cycloperoxide functionality, and revealed other structural features critical for antimalarial activity, namely the "Western" alkyl side chain, the dioxane ring conformation, and the absolute configuration of the stereogenic carbons on the 1,2-doxane ring, when affecting the bioactive ring conformed.
Polyacetylenes from Sardinian Oenanthe fistulosa: A Molecular Clue to risus sardonicus
Oenanthotoxin and dihydrooenanthot toxin were found to potently block GABAergic responses, providing a molecular rationale for the symptoms of poisoning from water-dropwort (Oenanthe crocata) and related plants.
Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase I activity.
Bioactivity-guided fractionation of the leaf methanolic extract of P. peltata, using the brine shrimp lethality test, led to the isolation of catechol derivative 4-nerolidylcatechol (4-NC), suggesting that this could be a possible mechanism for the cytotoxicity observed in KB cells.