• Publications
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Punctuated Evolution of Prostate Cancer Genomes
The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes, but the spectrum of genome-wide alterations has not been profiled extensively in this disease. We sequencedExpand
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Plasma AR and abiraterone-resistant prostate cancer
Androgen receptor mutations and amplifications in circulating tumor DNA provide clues to prostate cancer drug resistance. Detecting resistance before it starts Androgen receptor targeting is theExpand
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Tumor clone dynamics in lethal prostate cancer
Independent clones with distinct genomic patterns show complex dynamics over the lethal course of prostate cancer, with gradual emergence of drug-resistant clones. Treacherous Evolution of ProstateExpand
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Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response.
IMPORTANCE Understanding molecular mechanisms of response and resistance to anticancer therapies requires prospective patient follow-up and clinical and functional validation of both common andExpand
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A highly specific SpCas9 variant is identified by in vivo screening in yeast
Despite the utility of CRISPR–Cas9 nucleases for genome editing, the potential for off-target activity limits their application, especially for therapeutic purposes. We developed a yeast-based assayExpand
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The Beta Workbench: a computational tool to study the dynamics of biological systems
We introduce the Beta Workbench (BWB), a scalable tool built on top of the newly defined BlenX language to model, simulate and analyse biological systems. We show the features and the incrementalExpand
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The BlenX Language: A Tutorial
This paper presents a new programming language, BlenX. BlenX is inspired to the process calculus Beta-binders and it is intended for modelling any system whose basic step of computation is anExpand
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A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers
Purpose: Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer that may develop de novo or as a mechanism of treatment resistance. N-myc is capable of driving NEPCExpand
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ASEQ: fast allele-specific studies from next-generation sequencing data
BackgroundSingle base level information from next-generation sequencing (NGS) allows for the quantitative assessment of biological phenomena such as mosaicism or allele-specific features in healthyExpand
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Modelling and simulation of biological processes in BlenX
We introduce a scalable framework built upon the BlenX language and inspired by the Beta-binders process calculus to model, simulate and analyse biological systems. We show the features of the BetaExpand
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