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The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation.
Activity in the context of the short promoter was abolished, but activity was restored in the presence of the upstream elements, showing that cooperation with factors binding to the CCAAT box and distal elements favors the functional interaction of the liver-specific APF/HNF1 factor with lower-affinity binding sites. Expand
Anatomy of the rat albumin promoter.
The results suggest that the upstream elements contribute to promoter activity by stabilizing the HNF1-PE complex and not by direct interaction with TFIID or the RNA polymerase. Expand
NFY or a related CCAAT binding factor can be replaced by other transcriptional activators for co-operation with HNF1 in driving the rat albumin promoter in vivo.
It is proposed that during development NFY could facilitate transcription of the albumin gene in hepatocytes when the concentration of HNF1 is limiting, as the CCAAT-box can be replaced by AP1, SP1 or E2 target sites without significantly affecting the final activity. Expand
Rectal stenosis following the use of suppositories containing paracetamol and acetylsalicylic acid
The authors report the case of a 74-year-old woman presenting a rectal stenosis that arose after the prolonged use of suppositories containing an association of paracetamol and acetylsalicylic acidExpand
The rat albumin promoter is composed of six distinct positive elements within 130 nucleotides.
The mapping of these regulatory elements in vivo entirely coincided with footprint data obtained in vitro, thereby allowing the tentative assignment of specific factors to the effects observed in vivo. Expand
Regulation of albumin gene expression in hepatoma cells of fetal phenotype: dominant inhibition of HNF1 function and role of ubiquitous transcription factors.
It is concluded that hepatoma cells of the fetal phenotype are deficient in the use of H NF1 to drive transcription of the albumin gene and that they harbor a dominant modulator of HNF1 function. Expand
Human genome dispersal and evolution of 4q35 duplications and interspersed LSau repeats.
The findings suggest that duplications and repeated sequences have undergone different expansion/contraction events during evolution, and the mechanisms underlying the dispersal of paralogous regions may be further derived through studies comparing the detailed structural organization of these genomic regions in man and primates. Expand
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants.
Results suggest that in AT fibroblasts, where only the ATM gene is mutated, ATM-independent mechanisms prevent gene amplification, while, in the immortalized hamster cell lines, which are already permissive for gene amplified, the AT-like defect increases the probability of gene amplification. Expand