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Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
Of Microbes and Cancer Inflammation is a well-established driver of tumorigenesis. For example, patients with inflammatory bowel disease have an elevated risk of developing colorectal cancer (CRC).Expand
Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis
Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in eukaryotes, a very highly conserved protective mechanism. HSF1 function increases survival under a great manyExpand
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
Colitis-associated cancer (CAC) is a major complication of inflammatory bowel diseases. We show that components of the inflammasome are protective during acute and recurring colitis and CAC in theExpand
Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-doseExpand
Gastric Cancer Originating from Bone Marrow-Derived Cells
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow–derived cells (BMDCs), which are frequently recruited to sites of tissue injury andExpand
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling.
In vitro data suggest that a subgroup of NLR proteins, including NLRP12, inhibits the transcription factor NF-κB, although physiologic and disease-relevant evidence is largely missing. DysregulatedExpand
Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds
Human embryonic stem (hES) cells hold promise as an unlimited source of cells for transplantation therapies. However, control of their proliferation and differentiation into complex, viable 3DExpand
Activation of β-catenin by carcinogenic Helicobacter pylori
Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a fraction of colonized persons ever develop gastric cancer.Expand
Critical Roles for stx2,eae, and tir in EnterohemorrhagicEscherichia coli-Induced Diarrhea and Intestinal Inflammation in Infant Rabbits
ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) is a group of food-borne pathogens that can cause diarrhea, colitis, and the hemolytic uremic syndrome (HUS). The importance of several of theExpand
Activation of beta-catenin by carcinogenic Helicobacter pylori.
Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a fraction of colonized persons ever develop gastric cancer.Expand
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