A. Roger

Publications228
h-index65
Citations15,306
Highly Influential Citations976
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Phylogeny of Dissimilatory Sulfite Reductases Supports an Early Origin of Sulfate Respiration
TLDR
It is concluded that the high similarity of bacterial and archaeal DSRs reflects their common origin from a conserved DSR, which was either present before the split between the domains Bacteria, Archaea, and Eucarya or laterally transferred between Bacteria and Archaea soon after domain divergence. Expand
A kingdom-level phylogeny of eukaryotes based on combined protein data.
TLDR
The sequences of four of the most broadly taxonomically sampled proteins available are combined to create a roughly parallel data set to that of SSU rRNA, showing strong support for most major groups and several major supergroups. Expand
Phylogenomic analyses support the monophyly of Excavata and resolve relationships among eukaryotic “supergroups”
  • V. Hampl, L. Hug, +4 authors A. Roger
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 10 March 2009
TLDR
A phylogenomic analysis of a dataset of 143 proteins and 48 taxa indicates that Excavata forms a monophyletic suprakingdom-level group that is one of the 3 primary divisions within eukaryotes, along with unikonts and a megagroup of Archaeplastida, Rhizaria, and the chromalveolate lineages. Expand
The tree of eukaryotes.
TLDR
Recent progress in assembling the tree of eukaryotes is reviewed, describing the major evidence for each supergroup, and where gaps in the authors' knowledge remain. Expand
Multiple Lateral Transfers of Dissimilatory Sulfite Reductase Genes between Major Lineages of Sulfate-Reducing Prokaryotes
  • Michael Klein, Michael Friedrich, +6 authors Michael Wagner
  • Biology, Medicine
  • Journal of bacteriology
  • 15 October 2001
TLDR
Findings complicate the use of dsrAB genes to infer phylogenetic relationships among sulfate reducers in molecular diversity studies, but establish a framework to resolve the origins and diversification of this ancient respiratory lifestyle among organisms mediating a key step in the biogeochemical cycling of sulfur. Expand
Testing congruence in phylogenomic analysis.
TLDR
Concaterpillar, a hierarchical clustering method based on likelihood-ratio testing that identifies congruent loci for phylogenomic analysis, is developed, which produces a phylogeny with stronger support for five eukaryote supergroups including the Opisthokonts, the Plantae, the stramenopiles + Apicomplexa, the Amoebozoa, and the Excavata. Expand
The real ‘kingdoms’ of eukaryotes
TLDR
This paper presents a meta-analyses of the determinants of infectious disease in eight operation theatres of the immune system and three of them are connected to each other through the immune checkpoint system. Expand
Ancient origin of the integrin-mediated adhesion and signaling machinery
TLDR
A comparative genomic analysis of the integrin adhesion machinery is reported, finding that core components are encoded in the genome of the apusozoan protist Amastigomonas sp. Expand
Toward Resolving the Eukaryotic Tree: The Phylogenetic Positions of Jakobids and Cercozoans
TLDR
The first large-scale eukaryotic phylogeny is reported, inferred from 143 nucleus-encoded proteins comprising 31,604 amino acid positions, that includes jakobids, malawimonads and cercozoans, and compelling support is obtained for the monophyly of JEH group, Euglenozoa plus Heterolobosea (JEH group), and for the association of cer cozoans with stramenopiles plus alveolates. Expand
Direct evidence for secondary loss of mitochondria in Entamoeba histolytica.
  • C. Clark, A. Roger
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 3 July 1995
TLDR
Direct evidence for secondary loss of mitochondrial function was obtained by isolating two E. histolytica genes encoding proteins that in other eukaryotes are localized in the mitochondrion: the enzyme pyridine nucleotide transhydrogenase and the chaperonin cpn60. Expand
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