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Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.
Human intervention trials have provided evidence for protective effects of various (poly)phenol-rich foods against chronic disease, including cardiovascular disease, neurodegeneration, and cancer.Expand
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Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into
BACKGROUND There are very limited data regarding the effects of blueberry flavonoid intake on vascular function in healthy humans. OBJECTIVES We investigated the impact of blueberry flavonoidExpand
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Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study.
BACKGROUND The absorption of cocoa flavanols in the small intestine is limited, and the majority of the flavanols reach the large intestine where they may be metabolized by resident microbiota. Expand
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Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
There is substantial interest in the role of plant secondary metabolites as protective dietary agents. In particular, the involvement of flavonoids and related compounds has become a major topic inExpand
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Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men.
Regular consumption of green tea polyphenols (GTP) is thought to reduce the risk of cardiovascular disease (CVD) but has also been associated with liver toxicity. The present trial aimed to assessExpand
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The neuroprotective potential of flavonoids: a multiplicity of effects
Flavonoids exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation,Expand
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Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease.
A nitric oxide synthase (NOS)-like activity has been demonstrated in human red blood cells (RBCs), but doubts about its functional significance, isoform identity and disease relevance remain. UsingExpand
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Addressing the inter‐individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction
Bioactive compounds in plant‐based foods have health properties that contribute to the prevention of age‐related chronic diseases, particularly cardiometabolic disorders. Conclusive proof andExpand
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Berry (poly)phenols and cardiovascular health.
Berries are a rich source of (poly)phenols, including anthocyanins, flavan-3-ols, procyanidins, flavonols, ellagitannins, and hydroxycinnamates. Epidemiological evidence indicates that theExpand
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Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study
Abstract Cocoa flavanol (CF) intake improves endothelial function in patients with cardiovascular risk factors and disease. We investigated the effects of CF on surrogate markers of cardiovascularExpand
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