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Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.
- D. Del Rio, A. Rodriguez-Mateos, J. Spencer, M. Tognolini, G. Borges, A. Crozier
- Biology, MedicineAntioxidants & redox signaling
- 10 May 2013
It is concluded that better performed in vivo intervention and in vitro mechanistic studies are needed to fully understand how (poly)phenol molecules interact with human physiological and pathological processes.
Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into…
- A. Rodriguez-Mateos, C. Rendeiro, J. Spencer
- MedicineThe American journal of clinical nutrition
- 1 November 2013
Blueberry intake acutely improves vascular function in healthy men in a time- and intake-dependent manner and may be mechanistically linked to the actions of circulating phenolic metabolites on neutrophil NADPH oxidase activity.
Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study.
- X. Tzounis, A. Rodriguez-Mateos, J. Vulevic, G. Gibson, C. Kwik-Uribe, J. Spencer
- Biology, MedicineThe American journal of clinical nutrition
It is shown, for the first time to the authors' knowledge, that consumption of cocoa flavanols can significantly affect the growth of select gut microflora in humans, which suggests the potential prebiotic benefits associated with the dietary inclusion of flavanol-rich foods.
Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men.
The present data suggests that the daily consumption of high doses of GTP by healthy men for 3 wk is safe but without effects on CVD risk biomarkers other than the total:HDL cholesterol ratio.
Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action
- Dr David Vauzour, A. Rodriguez-Mateos, G. Corona, M. Oruña‐Concha, J. Spencer
- 1 November 2010
The role that polyphenols play in the prevention of cancer, cardiovascular disease and neurodegeneration is provided and epidemiological data, human intervention study findings, as well as animal and in vitro studies in support of these actions are presented.
The neuroprotective potential of flavonoids: a multiplicity of effects
- Dr David Vauzour, K. Vafeiadou, A. Rodriguez-Mateos, C. Rendeiro, J. Spencer
- BiologyGenes & Nutrition
- 21 October 2008
The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs.
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.
Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols.
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
- A. Rodriguez-Mateos, Dr David Vauzour, A. Crozier
- Biology, MedicineArchives of Toxicology
- 3 September 2014
Recent findings on the bioavailability and biological activity of (poly)phenols are summarized, focusing on the epidemiological and clinical evidence of beneficial effects of flavonoids and related compounds on urinary tract infections, cognitive function and age-related cognitive decline, cancer and cardiovascular disease.
Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease.
It is demonstrated that human RBCs contain an endothelial NOS (eNOS) that converts L-(3)H-arginine to L-citrulline in a Ca(2+)/calmodulin-dependent fashion and in patients with coronary artery disease, red cell eNOS expression and activity are lower than in age-matched healthy individuals and correlate with the degree of endothelial dysfunction.