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Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting
Stressful life events have been implicated clinically in the pathogenesis of mental illness, but the neural substrates that may account for this observation remain poorly understood. AttentionalExpand
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Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex.
The prefrontal cortex (PFC) plays an important role in higher cognitive processes, and in the regulation of stress-induced hypothalamic-pituitary-adrenal (HPA) activity. Here we examined the effectExpand
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Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
Both the hippocampus and the medial prefrontal cortex (mPFC) play an important role in the negative feedback regulation of hypothalamic-pituitary-adrenal (HPA) activity during physiologic andExpand
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New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales
Cognitive impairment in normal aging and neurodegenerative diseases is accompanied by altered morphologies on multiple scales. Understanding of the role of these structural changes in producingExpand
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Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
Recent epidemiological evidence indicates that insulin resistance, a proximal cause of Type II diabetes [a non‐insulin dependent form of diabetes mellitus (NIDDM)], is associated with an increasedExpand
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Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs
In the rTg4510 mouse model, expression of the mutant human tau variant P301L leads to development of neurofibrillary tangles (NFTs), neuronal death, and memory impairment, reminiscent of theExpand
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Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys.
Alterations in neuronal morphology occur in primate cerebral cortex during normal aging, vary depending on the neuronal type, region and cortical layer, and have been related to memory and cognitiveExpand
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Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress
Apical dendritic retraction and axospinous synapse loss in the medial prefrontal cortex (PFC) are structural alterations that result from repeated restraint stress. Such changes in this brain regionExpand
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Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Anatomical alterations in the medial prefrontal cortex (mPFC) are associated with hypothalamopituitary adrenal (HPA) axis dysregulation, altered stress hormone levels, and psychiatric symptoms ofExpand
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Changes in the structural complexity of the aged brain
Structural changes of neurons in the brain during aging are complex and not well understood. Neurons have significant homeostatic control of essential brain functions, including synapticExpand
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