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Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.
Species Variation in the Mechanisms of Mesenchymal Stem Cell‐Mediated Immunosuppression
Bone marrow‐derived mesenchymal stem cells (MSCs) hold great promise for treating immune disorders because of their immunoregulatory capacity, but the mechanism remains controversial. As we show…
Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression
A novel function of adhesion molecules in immunoregulation by MSCs is revealed and new insights for the clinical studies of antiadhesion therapies in various immune disorders are provided.
How mesenchymal stem cells interact with tissue immune responses.
Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed…
The selective expression of TECK and GPR-9-6 in thymus and small intestine implies a dual role for GPR/CCR-9, both in T cell development and the mucosal immune response, and proposes the designation CCR-9 for this chemokine receptor.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know
The hematopoietic system of GM-CSF-deficient mice appears to be normal; the most significant changes are in some specific T cell responses.
CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα.
Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment
- E. Kunkel, James J. Campbell, W. Agace
- Biology, MedicineThe Journal of experimental medicine
- 4 September 2000
Results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract.
Cutting Edge: NKG2D Receptors Induced by IL-15 Costimulate CD28-Negative Effector CTL in the Tissue Microenvironment1
This work reports that NKG2D, the receptor for stress-induced MICA and MICB molecules expressed in the intestine, serves as a potent costimulatory receptor for CTL freshly isolated from the human intestinal epithelium, which is regulated by IL-15.