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Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.
It is found that proinflammatory cytokines are required to induce immunosuppression by MSCs through the concerted action of chemokines and NO. Expand
Species Variation in the Mechanisms of Mesenchymal Stem Cell‐Mediated Immunosuppression
Bone marrow‐derived mesenchymal stem cells (MSCs) hold great promise for treating immune disorders because of their immunoregulatory capacity, but the mechanism remains controversial. As we showExpand
Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression
A novel function of adhesion molecules in immunoregulation by MSCs is revealed and new insights for the clinical studies of antiadhesion therapies in various immune disorders are provided. Expand
How mesenchymal stem cells interact with tissue immune responses.
A synthesis of the current status of mesenchymal stem cells is provided, which shows that there are bidirectional interactions between MSCs and inflammatory cells, which determine the outcome of MSC-mediated tissue repair processes. Expand
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know
The hematopoietic system of GM-CSF-deficient mice appears to be normal; the most significant changes are in some specific T cell responses. Expand
Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed
The selective expression of TECK and GPR-9-6 in thymus and small intestine implies a dual role for GPR/CCR-9, both in T cell development and the mucosal immune response, and proposes the designation CCR-9 for this chemokine receptor. Expand
Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment
Results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. Expand
Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease☆☆☆
In active celiac disease, there is a specific and selective increase of IELs expressing CD94, the HLA-E–specific NK receptor that may be related to T-cell receptor activation and/or interleukin 15 secretion. Expand
CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα.
It is demonstrated that, in an inflammatory environment, tumor-resident MSCs promote tumor growth by recruiting monocytes/macrophages. Expand
Mesenchymal stem cells: a double-edged sword in regulating immune responses
  • W. Li, G. Ren, +13 authors Y. Shi
  • Biology, Medicine
  • Cell Death and Differentiation
  • 16 March 2012
It is shown that Mesenchymal stem cells can also enhance immune responses, and the dual effect on immune reactions was also observed in human MSCs, in which indoleamine 2,3-dioxygenase (IDO) acts as a switch. Expand