• Publications
  • Influence
Effect of lymphatic and splenic pump techniques on the antibody response to hepatitis B vaccine: a pilot study.
TLDR
Data suggest an enhanced immunologic response in subjects who received OMT, and the average anti-hepatitis B titer was higher in the treatment group than in the control group. Expand
A Sweet Connection? Fructose’s Role in Hepatocellular Carcinoma
TLDR
The current understanding of fructose metabolism in liver disease and liver tumor development is summarized and the latest knowledge of cancer cell metabolism is considered to speculate on additional mechanisms ofructose metabolism in hepatocellular carcinoma. Expand
Coronary artery disease: Darapladib fails to improve the STABILITY of CAD
  • A. Roberts
  • Medicine
  • Nature Reviews Cardiology
  • 15 April 2014
TLDR
The STABILITY investigators postulate that darapladib might have less of an effect on atherosclerotic plaque than was thought previously, or that the excellent background therapy received by the study participants left little scope for additional benefit from daraPladib. Expand
Anticoagulation therapy: Otamixaban fails in NSTE-ACS
  • A. Roberts
  • Medicine
  • Nature Reviews Cardiology
  • 17 September 2013
The findings of the TAO trial do not support the use of the novel factor Xa inhibitor otamixaban in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) undergoing an invasiveExpand
Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand 18F-GE-180 and comparison with 18F-FDG and DCE-MRI
TLDR
The correlations between DCE-MRI parameters and 18F-FDG uptake support use of this PET tracer for quantification of inflammatory burden in RA. Expand
Biomarkers: hs-cTnT measurement to rule out MI
  • A. Roberts
  • Medicine
  • Nature Reviews Cardiology
  • 15 April 2014
A single-centre study conducted in Sweden has demonstrated that measurement of cardiac troponin T level using a highsensitivity assay (hs-cTnT) could rule out myocardial infarction (MI) in patientsExpand
Genetics: Potassium channelopathy implicated in the pathogenesis of familial PAH
  • A. Roberts
  • Medicine
  • Nature Reviews Cardiology
  • 13 August 2013
TLDR
Functional in vitro studies of the six mutations identified in the genetic analyses revealed a loss of function of the human KCNK3 channel at physiological pH, and the investigators speculate that the six GENETICS may be responsible for this loss. Expand
Molecular cross-talk between the liver and white adipose tissue links excessive noURIshment to hepatocellular carcinoma
TLDR
It is shown that chronically high expression of both proteins induces DNA damage, followed by systemic inflammation, which initiates non-alcoholic steatohepatitis (NASH) and HCC, and suggests that targeting URI and IL-17 levels may be a useful therapeutic strategy in the treatment of obesity-driven HCC. Expand
Cardiac resuscitation: The 'smoker's paradox' after in-hospital cardiac arrest
  • A. Roberts
  • Medicine
  • Nature Reviews Cardiology
  • 20 May 2014
TLDR
The investigators postulate that the improved outcomes in smokers “can potentially be explained by the phenomenon of ischaemic preconditioning,” whereby the hypoxic effects of tobacco smoke induce periodic episodes of minor ischaemia and reperfusion that can blunt the effects of sustained and dramatic reperfusions injury, such as that occurring after CPR. Expand
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