• Publications
  • Influence
Cytoprotection by Prostaglandins in Rats Prevention of Gastric Necrosis Produced by Alcohol, HCl, NaOH, Hypertonic NaCl, and Thermal Injury
TLDR
It is suggested that certain prostaglandins, by a mechanism other than the inhibition of gastric acid secretion, maintain the cellular integrity of the gastric mucosa, and might be beneficial in the treatment of a variety of diseases in which Gastric mucosal injury is present. Expand
Cytoprotection by prostaglandins.
  • A. Robert
  • Biology, Medicine
  • Gastroenterology
  • 1 October 1979
TLDR
A new property of PG was discovered, called "cytoprotection,"!' which designates the prop- erty of many PG to protect the mucosa of the stom- ach and the intestine from becoming inflamed and necrotic, when this mucosa is exposed to noxious agents. Expand
Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.
TLDR
The results suggest that certain prostaglandins, by a mechanism other than the inhibition of gastric acid secretion, maintain the cellular integrity of the gastric mucosa, and might be beneficial in the treatment of a variety of diseases in which Gastric mucosal injury is present. Expand
Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins.
TLDR
Mild irritants, given intragastrically, are also cytoprotective by stimulating the release of PG by the stomach, and the increased synthesis of PG may represent a physiological, natural defense mechanism that may be necessary to maintain cellular integrity of the gastrointestinal mucosa, in spite of the hostile environment caused by luminal contents. Expand
Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins.
  • A. Robert
  • Chemistry, Medicine
  • Advances in prostaglandin and thromboxane…
  • 1976
Cytoprotection by prostaglandins.
  • A. Robert
  • Medicine
  • Scandinavian journal of gastroenterology…
  • 1981
Enteropooling assay: a test for diarrhea produced by prostaglandins.
TLDR
The hypothesis that the diarrhea observed after administration of high doses of prostaglandins is due to accumulation of abundant fluid into the small intestine, and not intestinal hypermotility, is supported. Expand
Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying.
TLDR
IL-1 is the most potent of known agents that are gastric cytoprotective, antiulcer, antisecretory, and delay gastric emptying, and these studies suggest that the stomach possesses IL-1 receptors. Expand
Inhibition of gastric secretion by prostaglandins
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