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Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines.
- A. Rivenson, D. Hoffmann, B. Prokopczyk, S. Amin, S. Hecht
- Chemistry, Medicine
- Cancer research
- 1 December 1988
The observation of benign and malignant tumors of the lung and pancreas of rats treated with the tobacco-specific nitrosamines NNK and NNAL is discussed in respect to the causal association between cigarette smoking and cancer of the Lung and Pancreas. Expand
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
Investigation of the chemopreventive action of dietary curcumin on azoxymethane-induced colon carcinogenesis and also the modulating effect of this agent on the colonic mucosal and tumor phospholipase A2, phospholIPase C gamma 1, lipoxygenase, and cyclo oxygengenase activities in male F344 rats indicates that dietary administration ofCurcumin significantly inhibited incidence of colon adenocarcinomas. Expand
Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.
It is suggested that Bifidobacterium supplements in the diet inhibit IQ-induced colon and liver tumors and to a lesser extent mammary tumors in F344 rats. Expand
A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.
There was an increasing trend of development of pancreas tumors in these control rats with aging regardless of dietary fat variance, and this study points to the importance of evaluating both exposure to tobacco carcinogens and dietary fat intake as risk factors for tobacco users. Expand
3-(Methylnitrosamino)propionitrile: occurrence in saliva of betel quid chewers, carcinogenicity, and DNA methylation in F344 rats.
- B. Prokopczyk, A. Rivenson, P. Bertinato, K. Brunnemann, D. Hoffmann
- Cancer research
- 15 January 1987
It is demonstrated that MNPN is present in the saliva of betel quid chewers and is a potent carcinogen in F344 rats. Expand
Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats
- D. Hoffmann, A. Rivenson, S. Amin, S. Hecht
- Chemistry, Medicine
- Journal of Cancer Research and Clinical Oncology
Bioassays at lower dose levels as well as biochemical studies are strongly indicated for NNN and NNK since these nitrosamines occur in relatively high amounts in both chewing tobacco and tobacco smoke. Expand
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.
Results indicate that dietary sulindac at 160 and 320 ppm levels inhibited the incidence of invasive and noninvasive adenocarcinomas of the colon and suppressed the colon tumor volume in a dose-dependent manner. Expand
Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis.
- J. Singh, A. Rivenson, M. Tomita, S. Shimamura, N. Ishibashi, B. Reddy
- Biology, Medicine
- 1 April 1997
Data suggest that oral administration of probiotic B. longum exerts strong antitumor activity, as indicated by modulation of the intermediate biomarkers of colon cancer, and consequently reduced tumor outcome. Expand
Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats.
The carcinogenic activity of PhIP, given by gavage, in the mammary gland of CD rats is described and the carcinogenic potency observed under identical conditions, of three agents (B[a]P congruent to PhIP > 1-NP) that are prevalent in the human environment are ranked. Expand
The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung.
It is the working hypothesis that more intense smoking, deeper inhalation of the smoke, and higher smoke delivery of the organ-specific lung carcinogen NNK to the peripheral lung are major contributors to the increased risk of cigarette smokers for lung adenocarcinoma. Expand