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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
TLDR
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation. Expand
Hundreds of variants clustered in genomic loci and biological pathways affect human height
TLDR
It is shown that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait, and indicates that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways. Expand
Epidemiology and course of anorexia nervosa in the community.
TLDR
The authors found a substantially higher lifetime prevalence and incidence of anorexia nervosa than reported in previous studies, most of which were based on treated cases. Expand
Breakfast skipping and health-compromising behaviors in adolescents and adults
TLDR
Breakfast skipping is associated with health-compromising behaviors in adults and adolescents and individuals and families who skip breakfast may benefit from preventive efforts that also address risk behaviors other than eating patterns. Expand
How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement
A consensus meeting was held in Bangkok, 21–23 May 2002, where experts and young scientists in the field of physical activity, energy expenditure and body‐weight regulation discussed the differentExpand
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
TLDR
A meta-analysis of genome-wide association studies for WHR adjusted for body mass index provides evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions. Expand
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.
TLDR
The NAFLD liver fat score and liver fat equation provide simple and noninvasive tools to predict non-alcoholic fatty liver disease and liverfat content. Expand
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
TLDR
CB1 blockade with rimonabant 20 mg, combined with a hypocaloric diet over 1 year, promoted significant decrease of bodyweight and waist circumference, and improvement in cardiovascular risk factors. Expand
Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients
TLDR
Orlistat taken with an appropriate diet promotes clinically significant weight loss and reduces weight regain in obese patients over a 2 year period and the use of orlistat beyond 2 years needs careful monitoring with respect to efficacy and adverse events. Expand
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index
TLDR
Genetic loci associated with body mass index map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor, which may provide new insights into human body weight regulation. Expand
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