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Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients.
Evidence of an age-related decline of plasma ghrelin concentrations is provided, which might explain, at least partially, the somatotroph dysregulation and the anorexia of the elderly subject.
Children with Prader-Willi syndrome exhibit more evident meal-induced responses in plasma ghrelin and peptide YY levels than obese and lean children.
The finding of a meal-induced decrease and increase in ghrelin and PYY levels respectively in PWS children would imply that the regulation of appetite/satiety of these peptides is operative during childhood, and it progressively deteriorates and vanishes in adulthood when hyperphagia and obesity worsen.
TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity
Biochemical and molecular analyses suggest that TLQP-21 exerts its effects by stimulating autonomic activation of adrenal medulla and adipose tissues and prove that its chronic i.c.v. infusion effected an increase in EE and limited the early phase of diet-induced obesity.
Maintenance of a normal meal-induced decrease in plasma ghrelin levels in children with Prader-Willi syndrome.
The finding of a meal-induced decrease in ghrelin levels in the population of young PWS would imply that the regulation of the gh Relin system involved in the orexigenic effects of the peptide is operative during childhood, although it progressively deteriorates and is absent in adulthood when hyperphagia and obesity progressively worsen.
Growth Hormone-Releasing Effects of Whole Body Vibration Alone or Combined with Squatting plus External Load in Severely Obese Female Subjects
WBV alone stimulates GH release and lactate production in severely obese female subjects, with no additive effect when combined with squatting plus external load.
Effects of an acute bout of exercise on circulating extracellular vesicles: tissue-, sex-, and BMI-related differences
Though preliminary, the results of the present study show that a single bout of acute exercise modulates the release of EVs in circulation, which are tissue-, sex-, and BMI specific, suggesting that the exercise-related benefits might depend upon a complex interaction of tissue, endocrine, and metabolic factors.