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CD95 Signaling via Ceramide-rich Membrane Rafts*
Clustering seems to be employed by many receptors for transmembrane signaling. Here, we show that acid sphingomyelinase (ASM)-released ceramide is essential for clustering of CD95.In vitro and inExpand
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Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts
Pseudomonas aeruginosa infection is a serious complication in patients with cystic fibrosis and in immunocompromised individuals. Here we show that P. aeruginosa infection triggers activation of theExpand
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CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa.
Pseudomonas aeruginosa causes severe infections, particularly of the lung, that are life threatening. Here, we show that P. aeruginosa infection induces apoptosis of lung epithelial cells byExpand
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Ceramide-Rich Membrane Rafts Mediate CD40 Clustering1
Many receptor systems use receptor clustering for transmembrane signaling. In this study, we show that acid sphingomyelinase (ASM) is essential for the clustering of CD40. Stimulation of lymphocytesExpand
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Membrane rafts in host-pathogen interactions.
Central elements in the infection of mammalian cells with viral, bacterial and parasitic pathogens include the adhesion of the pathogen to surface receptors of the cell, recruitment of additionalExpand
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Rhinoviruses Infect Human Epithelial Cells via Ceramide-enriched Membrane Platforms*
The cell membrane contains very small distinct membrane domains enriched of sphingomyelin and cholesterol that are named rafts. We have shown that the formation of ceramide via activation of the acidExpand
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Invasion of Human Epithelial Cells byPseudomonas aeruginosa Involves Src-Like Tyrosine Kinases p60Src and p59Fyn
ABSTRACT Pseudomonas aeruginosa plays a major role in respiratory tract infections or sepsis in patients with cystic fibrosis or upon suppression of the immune system. Several P. aeruginosa strainsExpand
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CD95-mediated apoptosis in vivo involves acid sphingomyelinase.
Acid sphingomyelinase (ASM) is reported to have an essential function in stress-induced apoptosis although the physiological function of ASM in receptor-triggered apoptosis is unknown. Here, weExpand
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Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis
Pulmonary edema associated with increased vascular permeability is a severe complication of Staphylococcus aureus–induced sepsis and an important cause of human pathology and death. We investigatedExpand
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Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia
ABSTRACT Staphylococcus aureus plays an important role in sepsis, pneumonia, wound infections, and cystic fibrosis (CF), which is caused by mutations of the cystic fibrosis transmembrane conductanceExpand
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