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Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension.
Inhibition of thromboxane with an orally active agent is feasible in PPH, but the incidence of severe leg pain with terbogrel precludes its use in this disorder. Expand
The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites.
The results suggest that PAF could play a role in cardiac arrhythmias under special conditions and it supports the hypothesis thatPAF action is mediated by the release of leukotrienes and thromboxane. Expand
The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity.
- A. Riedel, P. Braquet, H. Mest
- Chemistry, Medicine
- Pharmacological research communications
- 1 October 1987
Platelet-activating factor (PAF) in a concentration of 10(-11) mole per animal decreased the threshold doses for onsets of arrhythmia, ventricular flutters and fibrillation in ouabain induced… Expand
Relevance of thromboxane-prostacyclin balance for cardiac rhythm disturbances.
Local effects of PAF in guinea-pig inner ear.
The effect of PAF-containing artificial perilymph at 10(-7) and 10(-8) M on the endocochlear potential (EP) was investigated in guinea-pigs. The inner ear was perfused and the EP recorded at the same… Expand
The effect of PAF in the cochlea of guinea pigs.
It is hypothesized that these PAF effects are due to an interference with ion transport in the non-sensory structures of the inner ear. Expand
PAF-antagonists and thromboxane (TX) antagonists abolish PAF-induced cardiac rhythym disturbances
WEB 2086, a novel specific PAF antagonist, prevents PAF induced arrhythmogenicity.
The hetrazepine derivative WEB 2086 (0.5-2 mg/kg, i.v.), a well known PAF receptor antagonist, was found to reduce the arrhythmogenic effect of PAF in a dose dependent manner on ouabain induced… Expand
The arrhythmogenic effect of platelet activating factor (PAF) is inhibited by PAF antagonist and by substances influencing eicosanoids.
The present study supports the hypothesis that PAF aggravates cardiac arrhythmias under pathophysiological conditions in which PAF is involved. Expand
Relevance of eicosanoids for biochemical regulation of cardiac rhythm disturbances.
Shifting the balance between the arrhythmogenic TX and the antiarrhythmic prostacyclin (PGI2) in favour of PGI2 by substances influencing the arachidonic acid cascade might by useful for the treatment of arrh rhythmias. Expand