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Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot
Many viruses regulate translation of polycistronic mRNA using a -1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi-continuous helix and two connectingExpand
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Structure of the DLM-1–Z-DNA complex reveals a conserved family of Z-DNA-binding proteins
The first crystal structure of a protein, the Zα high affinity binding domain of the RNA editing enzyme ADAR1, bound to left-handed Z-DNA was recently described. The essential set of residuesExpand
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Z-DNA: the long road to biological function
Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transientExpand
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A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains.
The double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is induced as part of the IFN response in mammals and acts to shut down protein synthesis by the phosphorylation of eukaryoticExpand
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Crystal structure of four-stranded Oxytricha telomeric DNA
The sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha telomere has been crystallized and its three-dimensional structure solved to 2.5 Å resolution. The oligonucleotide forms hairpins,Expand
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A role for Z-DNA binding in vaccinia virus pathogenesis
The N-terminal domain of the E3L protein of vaccinia virus has sequence similarity to a family of Z-DNA binding proteins of defined three-dimensional structure and it is necessary for pathogenicityExpand
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Biological function of the vaccinia virus Z-DNA-binding protein E3L: gene transactivation and antiapoptotic activity in HeLa cells.
  • J. Kwon, A. Rich
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 6 September 2005
The vaccinia virus (VV) E3L protein is essential for virulence and has anti-apoptotic activity. In mice, Z-DNA-binding activity of the N-terminal domain of E3L (Z alpha) is necessary for viralExpand
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Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody binding
Negative superhelical coiling of covalently closed DNA plasmids facilitates the formation of left-handed Z-DNA segments. This was demonstrated by binding of antibodies specific for Z-DNA. PlasmidExpand
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Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases
Left-handed Z-DNA is a higher-energy form of the double helix, stabilized by negative supercoiling generated by transcription or unwrapping nucleosomes. Regions near the transcription start siteExpand
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Translational control of protein synthesis in response to heat shock in D. melanogaster cells
In response to elevated temperature, Drosophila cells synthesize a small set of proteins known as the heat-shock proteins, while synthesis of most other proteins ceases. In vitro translation has beenExpand
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