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- Publications
- Influence
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot
Many viruses regulate translation of polycistronic mRNA using a -1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi-continuous helix and two connecting… Expand
Structure of the DLM-1–Z-DNA complex reveals a conserved family of Z-DNA-binding proteins
- T. Schwartz, J. Behlke, K. Lowenhaupt, U. Heinemann, A. Rich
- Biology, Medicine
- Nature Structural Biology
- 2001
The first crystal structure of a protein, the Zα high affinity binding domain of the RNA editing enzyme ADAR1, bound to left-handed Z-DNA was recently described. The essential set of residues… Expand
Z-DNA: the long road to biological function
Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient… Expand
A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains.
- S. Rothenburg, Nikolaus Deigendesch, +4 authors A. Rich
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 February 2005
The double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is induced as part of the IFN response in mammals and acts to shut down protein synthesis by the phosphorylation of eukaryotic… Expand
Crystal structure of four-stranded Oxytricha telomeric DNA
- C. Kang, X. Zhang, R. Ratliff, R. Moyzis, A. Rich
- Biology, Medicine
- Nature
- 12 March 1992
The sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha telomere has been crystallized and its three-dimensional structure solved to 2.5 Å resolution. The oligonucleotide forms hairpins,… Expand
A role for Z-DNA binding in vaccinia virus pathogenesis
- Yang-Gyun Kim, Maneesha Muralinath, +5 authors A. Rich
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 30 May 2003
The N-terminal domain of the E3L protein of vaccinia virus has sequence similarity to a family of Z-DNA binding proteins of defined three-dimensional structure and it is necessary for pathogenicity… Expand
Biological function of the vaccinia virus Z-DNA-binding protein E3L: gene transactivation and antiapoptotic activity in HeLa cells.
The vaccinia virus (VV) E3L protein is essential for virulence and has anti-apoptotic activity. In mice, Z-DNA-binding activity of the N-terminal domain of E3L (Z alpha) is necessary for viral… Expand
Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody binding
- A. Nordheim, E. Lafer, L. Peck, J. Wang, A. Rich
- Biology, Medicine
- Cell
- 1 December 1982
Negative superhelical coiling of covalently closed DNA plasmids facilitates the formation of left-handed Z-DNA segments. This was demonstrated by binding of antibodies specific for Z-DNA. Plasmid… Expand
Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases
- S. Ha, K. Lowenhaupt, A. Rich, Yang-Gyun Kim, K. Kim
- Chemistry, Medicine
- Nature
- 20 October 2005
Left-handed Z-DNA is a higher-energy form of the double helix, stabilized by negative supercoiling generated by transcription or unwrapping nucleosomes. Regions near the transcription start site… Expand
Translational control of protein synthesis in response to heat shock in D. melanogaster cells
In response to elevated temperature, Drosophila cells synthesize a small set of proteins known as the heat-shock proteins, while synthesis of most other proteins ceases. In vitro translation has been… Expand